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<p>Sensitive and accurate detection of biologically significant bilirubin is of great importance in the field of clinical diagnostics and disease monitoring. The present study introduces the TX-100 based nanomicellar fluorescent sensing platform <b>3@TX-100</b> comprising of 1,8-naphthalimide possessing schiff base and pyrene moiety for the selective and ultrasensitive detection of bilirubin in aqueous solutions. The proposed sensor <b>3@TX-100</b> exhibited an excellent <i>“turn-off”</i> fluorescence response toward bilirubin with an ultralow detection limit (LOD) of 0.68 nM. A concentration-dependent decrease in the emission intensity of <b>3@TX-100</b> was noted upon the addition of bilirubin, with saturation achieved at ~ 75 µM of bilirubin. Notably, the system displayed approximately 29-fold fluorescence quenching (≈ 96.6% decrease), highlighting the high sensitivity of the sensing platform. Furthermore, the <b>3@TX-100</b> ensemble displayed outstanding selectivity for bilirubin over 18 coexisting interferents. The mechanistic analysis confirmed that the sensing phenomenon is a result of synergistic hydrophobic, hydrogen bonding, and charge transfer interactions made possible by the TX-100 micellar environment. The binding constant between <b>3@TX-100</b> and bilirubin was estimated to be 3.55 × 10<sup>4</sup> M<sup>− 1</sup>. Overall, this work establishes <b>3@TX-100</b> as a water-compatible and highly sensitive nanomicellar sensing platform for the selective detection of biologically important bilirubin.</p>

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Design and fabrication of a naphthalimide@TX-100 nanomicellar fluorescent platform for highly sensitive and selective detection of bilirubin in aqueous environments

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月28日

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  • Ravina,
  • Nisha Jain,
  • Rishabh Chandel,
  • Priya Vashisht,
  • Navneet Kaur

摘要

Sensitive and accurate detection of biologically significant bilirubin is of great importance in the field of clinical diagnostics and disease monitoring. The present study introduces the TX-100 based nanomicellar fluorescent sensing platform 3@TX-100 comprising of 1,8-naphthalimide possessing schiff base and pyrene moiety for the selective and ultrasensitive detection of bilirubin in aqueous solutions. The proposed sensor 3@TX-100 exhibited an excellent “turn-off” fluorescence response toward bilirubin with an ultralow detection limit (LOD) of 0.68 nM. A concentration-dependent decrease in the emission intensity of 3@TX-100 was noted upon the addition of bilirubin, with saturation achieved at ~ 75 µM of bilirubin. Notably, the system displayed approximately 29-fold fluorescence quenching (≈ 96.6% decrease), highlighting the high sensitivity of the sensing platform. Furthermore, the 3@TX-100 ensemble displayed outstanding selectivity for bilirubin over 18 coexisting interferents. The mechanistic analysis confirmed that the sensing phenomenon is a result of synergistic hydrophobic, hydrogen bonding, and charge transfer interactions made possible by the TX-100 micellar environment. The binding constant between 3@TX-100 and bilirubin was estimated to be 3.55 × 104 M− 1. Overall, this work establishes 3@TX-100 as a water-compatible and highly sensitive nanomicellar sensing platform for the selective detection of biologically important bilirubin.