Scholarlink

<p>This study presents a pH-responsive, intestine-targeted, sustained-release curcumin delivery system based on a soy flour (SF) matrix reinforced with montmorillonite (MMT) and magnesium oxide (MgO), and crosslinked using glutaraldehyde (GA). The system addresses the limitations of curcumin’s poor solubility and instability in gastric conditions while offering a biopolymer-based alternative to conventional enteric coating strategies. The incorporation of MMT, MgO, and GA modulated encapsulation efficiency, matrix rigidity, and release rate, enabling optimisation of drug loading and sustained intestinal release. The optimised formulation demonstrated suppressed curcumin release in acidic medium (pH 1.2) and controlled prolonged release at pH 7.4, following anomalous (non-Fickian) transport. FTIR, XRD, and FESEM analyses confirmed uniform curcumin incorporation and structural reinforcement within the SF matrix. MTT assays verified high biocompatibility at low-to-moderate dopant levels, while 2-NBDG uptake studies demonstrated enhanced cellular glucose uptake, supporting the antidiabetic relevance. Overall, the findings highlight the potential of SF-based hybrid nanocomposites as a sustainable platform for controlled intestinal drug delivery in diabetes management.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A pH-responsive soy flour–montmorillonite–magnesium oxide complex for controlled release of curcumin in antidiabetic therapy

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月3日

查看全文
  • Dikshita Sharma,
  • Tarun K. Maji

摘要

This study presents a pH-responsive, intestine-targeted, sustained-release curcumin delivery system based on a soy flour (SF) matrix reinforced with montmorillonite (MMT) and magnesium oxide (MgO), and crosslinked using glutaraldehyde (GA). The system addresses the limitations of curcumin’s poor solubility and instability in gastric conditions while offering a biopolymer-based alternative to conventional enteric coating strategies. The incorporation of MMT, MgO, and GA modulated encapsulation efficiency, matrix rigidity, and release rate, enabling optimisation of drug loading and sustained intestinal release. The optimised formulation demonstrated suppressed curcumin release in acidic medium (pH 1.2) and controlled prolonged release at pH 7.4, following anomalous (non-Fickian) transport. FTIR, XRD, and FESEM analyses confirmed uniform curcumin incorporation and structural reinforcement within the SF matrix. MTT assays verified high biocompatibility at low-to-moderate dopant levels, while 2-NBDG uptake studies demonstrated enhanced cellular glucose uptake, supporting the antidiabetic relevance. Overall, the findings highlight the potential of SF-based hybrid nanocomposites as a sustainable platform for controlled intestinal drug delivery in diabetes management.