<p>An efficient and facile method has been developed for the synthesis of 3-indolylmethanamine via the Aza-Friedel Crafts Reaction of indole with imines by using Baker’s Yeast as biocatalyst. The reaction is very facile and works under mild and eco-friendly environment condition as ethyl alcohol (C₂H₅OH) is used as green solvent and Baker's Yeast as biocatalyst. Furthermore, the present method is very efficient as it requires simple work up and gives the products in good to excellent yields. It is anticipated that the present newly developed method will open a new route for the chemists to prepare the 3-indolylmethanamine via the Aza-Friedel Crafts Reaction of indole with imines in facile and eco-friendly environment.</p>