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<p><i>Salmonella</i> species are the most common food-borne pathogens that cause acute gastroenteritis in many developing countries. The growing numbers of antibiotic resistance strains represent a serious global threat to public health and worsen the situation. The emergence of <i>Salmonella</i> with reduced antibiotic susceptibility has been linked to the extensive use of antimicrobial agents in food animals and the routine practice of administering antimicrobial agents to animals as a means of preventing and treating diseases. This study aimed to determine the antibiotic resistance of <i>Salmonella</i> isolated from apparently healthy slaughtered cattle in selected towns’ abattoirs of Amhara National Regional State, Ethiopia. A total of 480 samples which include carcass swabs, liver, mesenteric lymph node and feces were collected from 120 animals. Eleven isolates, which were positive for <i>Salmonella</i> species were tested for their susceptibility pattern against 13 antimicrobial agents by Kirby–Bauer disk diffusion assay method. The study revealed that 9 out of 11 (81.8%) <i>Salmonella</i> isolates were multi-drug resistant (MDR). A high level of resistance was observed towards tetracycline (100%), followed by ampicillin (90.9%), sulphonamides (72.7%), amoxicillin (54.5%), and gentamicin (36.6%). However, low resistance was registered in norfloxacin (9.1%), ceftriaxone and cefotaxime (18.2%, each). None of the isolates was resistant to ciprofloxacin. Drug-resistant <i>Salmonella</i> isolated from abattoir samples highlight how cautiously antimicrobial medications should be used. It is difficult to develop preventative and control mechanism when multidrug-resistant <i>Salmonella</i> widely spread. Controlling the emergence and spread of antimicrobial resistance requires accurate and timely identification of drug resistance, followed by appropriate antimicrobial treatment and antimicrobial stewardship. A one Health approach could effectively manage the public health risks associated with resistant pathogens.</p>

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Antimicrobial resistance patterns of Salmonella isolates from slaughtered cattle in selected abattoirs of northwest Ethiopia

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月6日

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  • Muhammed Seid,
  • Worku Negash,
  • Abebe Olani,
  • Shubisa Abera,
  • Anwar Nuru

摘要

Salmonella species are the most common food-borne pathogens that cause acute gastroenteritis in many developing countries. The growing numbers of antibiotic resistance strains represent a serious global threat to public health and worsen the situation. The emergence of Salmonella with reduced antibiotic susceptibility has been linked to the extensive use of antimicrobial agents in food animals and the routine practice of administering antimicrobial agents to animals as a means of preventing and treating diseases. This study aimed to determine the antibiotic resistance of Salmonella isolated from apparently healthy slaughtered cattle in selected towns’ abattoirs of Amhara National Regional State, Ethiopia. A total of 480 samples which include carcass swabs, liver, mesenteric lymph node and feces were collected from 120 animals. Eleven isolates, which were positive for Salmonella species were tested for their susceptibility pattern against 13 antimicrobial agents by Kirby–Bauer disk diffusion assay method. The study revealed that 9 out of 11 (81.8%) Salmonella isolates were multi-drug resistant (MDR). A high level of resistance was observed towards tetracycline (100%), followed by ampicillin (90.9%), sulphonamides (72.7%), amoxicillin (54.5%), and gentamicin (36.6%). However, low resistance was registered in norfloxacin (9.1%), ceftriaxone and cefotaxime (18.2%, each). None of the isolates was resistant to ciprofloxacin. Drug-resistant Salmonella isolated from abattoir samples highlight how cautiously antimicrobial medications should be used. It is difficult to develop preventative and control mechanism when multidrug-resistant Salmonella widely spread. Controlling the emergence and spread of antimicrobial resistance requires accurate and timely identification of drug resistance, followed by appropriate antimicrobial treatment and antimicrobial stewardship. A one Health approach could effectively manage the public health risks associated with resistant pathogens.