Effectiveness of a new commercial ocular spray containing Biosecur in reducing conjunctival microbial flora as surgical prophylaxis in patients undergoing cataract surgery

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2024年10月2日

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Mario Damiano Toro,
Marina Concilio,
Maria Paola Laezza,
Diletta Mazzantini,
Emilia Ghelardi,
Aldo Gelso,
Mario Sbordone,
Ada Orrico,
Vincenzo De Angelis,
Francesco Calabrò,
Pasquale De Rosa,
Salvatore Mazzeo,
Dora Iula,
Francesco Perillo,
Claudia Rossi,
Ciro Costagliola

摘要

Introduction

This study is aimed to evaluate the antiseptic activity of a new ophthalmic spray containing Biosecur citrus extract as a preoperative prophylactic treatment in patients undergoing cataract intervention.

Methods

A prospective, multicenter study was conducted. Patients applied Oftasecur spray on the eye scheduled for surgery, three times daily for 3 days before surgery. Conjunctival swabs were performed before and after the treatment. Qualitative and quantitative microbiological analyses were assessed.

Results

Hundred and forty-seven patients (M: F = 76:71; mean age 70.74 ± 9.41 years) were enrolled. 58.5% of patients presented detectable microbial loads in the eye to be operated, before treatment. Most predominant bacterial species were: Staphylococcus epidermidis, coagulase-negative Staphylococci and Staphylococcus aureus. Patients were divided into three subgroups, according to the microbial loads measured at baseline: lower than 10 CFU/ml (41.7%), between 10 and 100 CFU/ml (31.7%), equal or greater than 100 CFU/ml (26.6%). A twofold reduction in positive patients who received Oftasecur: 44 eyes (51.2%) resulted in negative after ocular treatment. A significant reduction in bacterial loads was observed (p < 0.001). No ocular adverse reactions were recorded.

Conclusion

Oftasecur spray effectively reduced conjunctival bacterial burden. It may represent a proper and safe antiseptic adjuvant treatment in patients undergoing cataract surgery.