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Introduction <p>Percutaneous ablation techniques are increasingly used in pediatric oncology, yet electrochemotherapy has not been widely explored in children.</p> Case report <p>We report a 7-year-old girl with refractory metastatic neuroblastoma and bulky retroperitoneal residual disease considered inoperable after multiple chemotherapy regimens. Electrochemotherapy with interstitial injection of cisplatin was performed to control the residual metaiodobenzylguanidine-avid (MIBG) component compressing major vascular structures.</p> Conclusions <p>In neuroblastoma patients with unresectable primary disease, percutaneous ablation strategies such as electrochemotherapy may offer a safe adjunct to standard oncological approaches. Importantly, in this case, durable local control of the MIBG-avid residual tumor was achieved. Complex patients should be managed by expert multidisciplinary boards, and innovative local control techniques should be integrated with surgery within multimodal treatment strategies.</p>

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Electrochemotherapy as a potential local treatment for residual MIBG-avid disease in refractory pediatric neuroblastoma: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月28日

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  • Giulia Cassanelli,
  • Maria Antonietta De Ioris,
  • Gian Luigi Natali

摘要

Introduction

Percutaneous ablation techniques are increasingly used in pediatric oncology, yet electrochemotherapy has not been widely explored in children.

Case report

We report a 7-year-old girl with refractory metastatic neuroblastoma and bulky retroperitoneal residual disease considered inoperable after multiple chemotherapy regimens. Electrochemotherapy with interstitial injection of cisplatin was performed to control the residual metaiodobenzylguanidine-avid (MIBG) component compressing major vascular structures.

Conclusions

In neuroblastoma patients with unresectable primary disease, percutaneous ablation strategies such as electrochemotherapy may offer a safe adjunct to standard oncological approaches. Importantly, in this case, durable local control of the MIBG-avid residual tumor was achieved. Complex patients should be managed by expert multidisciplinary boards, and innovative local control techniques should be integrated with surgery within multimodal treatment strategies.