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<p>Vegetable waste is a promising bioresource for the production of nanomaterials. The eco-friendly synthesis of metallic nanoparticles is gaining attention among materials scientists, as biomolecules in vegetable waste show significant potential for nanoparticle synthesis. In the current study, an aqueous fruit pedicel extract of <i>Solanum torvum</i> was employed to produce silver nanoparticles (ST@AgNPs) using a green synthesis technique. UV-visible spectrum study corroborated the phytofabrication of ST@AgNPs, revealing a unique surface plasmon resonance peak at 418&#xa0;nm. The FTIR spectra were used to identify the efficient functional molecules that act as capping and stabilizing agents, as well as those that convert Ag + to nanosilver (Ag0). FE-SEM, TEM, and XRD indicated the crystalline nature of the spherical ST@AgNPs with an average size of ~ 108&#xa0;nm. Stability analysis indicates particle stability, with a surface charge of -16.2 mV based on zeta potential measurements. Antibacterial assays demonstrated significant inhibition of human pathogenic bacteria, including <i>Staphylococcus aureus</i>, <i>Klebsiella pneumoniae</i>, <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus haemolyticus.</i> The results of the agar broth dilution assay exhibited potential bacterial colony reduction at the lowest dose of ST@Ag-NPs. The results of the MTT cytotoxicity assay exhibit an anticancer efficacy against A549 lung cancer cells, with an IC₅₀ value of 38.2 ± 0.8&#xa0;µg/mL. This is the first study to examined the biogenesis and biological activity of ST@Ag-NPs derived from <i>S. torvum</i> fruit pedicel debris. These findings suggest that ST@Ag-NPs are effective for antibacterial and anticancer applications and may serve as a low-cost, bioactive therapeutic for future biomedical use.</p> Graphical Abstract <p></p>

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Antibacterial and cytotoxic effect of green synthesized silver nanoparticles using Solanum torvum fruit pedicel waste extract

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月31日

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  • Surendirakumar Kannaiah,
  • Suguna Paramasivam,
  • Bandana Sanasam,
  • Narmatha Sekar,
  • Kistu Singh Nongthombam,
  • Kavitha Palanivel,
  • Jeevan Pandiyan

摘要

Vegetable waste is a promising bioresource for the production of nanomaterials. The eco-friendly synthesis of metallic nanoparticles is gaining attention among materials scientists, as biomolecules in vegetable waste show significant potential for nanoparticle synthesis. In the current study, an aqueous fruit pedicel extract of Solanum torvum was employed to produce silver nanoparticles (ST@AgNPs) using a green synthesis technique. UV-visible spectrum study corroborated the phytofabrication of ST@AgNPs, revealing a unique surface plasmon resonance peak at 418 nm. The FTIR spectra were used to identify the efficient functional molecules that act as capping and stabilizing agents, as well as those that convert Ag + to nanosilver (Ag0). FE-SEM, TEM, and XRD indicated the crystalline nature of the spherical ST@AgNPs with an average size of ~ 108 nm. Stability analysis indicates particle stability, with a surface charge of -16.2 mV based on zeta potential measurements. Antibacterial assays demonstrated significant inhibition of human pathogenic bacteria, including Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa and Staphylococcus haemolyticus. The results of the agar broth dilution assay exhibited potential bacterial colony reduction at the lowest dose of ST@Ag-NPs. The results of the MTT cytotoxicity assay exhibit an anticancer efficacy against A549 lung cancer cells, with an IC₅₀ value of 38.2 ± 0.8 µg/mL. This is the first study to examined the biogenesis and biological activity of ST@Ag-NPs derived from S. torvum fruit pedicel debris. These findings suggest that ST@Ag-NPs are effective for antibacterial and anticancer applications and may serve as a low-cost, bioactive therapeutic for future biomedical use.

Graphical Abstract