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Introduction <p>Toxocariasis is one of the neglected parasitic infections globally. Exposure is highest where sanitation is poor and access to health care is limited. In Ghana, similar conditions exist in many rural and peri-urban communities. This study assessed the prevalence and determinants of toxocariasis in humans and dogs in Ghana.</p> Methods <p>A cross-sectional study was conducted in humans and dogs drawn from two regions of Ghana from January–October 2025. Human sera were tested for anti-<i>Toxocara</i> antibodies using serological assays, while faecal samples of dogs were analyzed using molecular methods.</p> Results <p>Human <i>Toxocara</i> seroprevalence was 14.5% (95% CI 11.4–17.5). Seropositivity was highest in children aged 6–15 years (23.9%, 95% CI 16.7–31.1) and lowest in the 16–30-year group (4.5%, 95% CI 0.6–8.3). Males (18.6%, 95% CI 13.9–23.3) and rural residents (27.5%, 95% CI 20.6–34.4) showed higher infection. Logistic regression showed that being male increased the odds of infection (AOR = 2.06; 95% CI 1.22–3.48), living in a rural area (AOR = 4.13; 95% CI 2.47–6.92) and having no formal education increased the likelihood of infection. Among dogs, the overall prevalence was 56.1% (95% CI 51.4–60.7). <i>T. canis</i> was the dominant species (87.9%), while <i>T. cati</i> accounted for 12.1%. Young dogs were much less likely to be infected than puppies (AOR = 0.18; 95% CI 0.10–0.30). Foreign-breed dogs had lower odds of infection than local breeds (AOR = 0.26; 95% CI 0.10–0.68).</p> Conclusion <p>The study reports on the burden of <i>Toxocara</i> exposure in both humans and dog populations. Children, males, rural residents, and individuals with no education were identified as risk groups. In dogs, puppies and local-breeds were found to be key reservoirs, highlighting their role in transmission dynamics. The findings underscore the importance of dog deworming, hygiene education and other One Health approaches to reduce the risk of transmission. This study provides the first molecular evidence of <i>Toxocara cati</i> infections in dogs in Ghana, warranting further investigation into cross-species transmission dynamics.</p>

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Molecular and serological surveillance of toxocariasis in humans and dogs in Ghana

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月12日

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  • Papa Kofi Amissah-Reynolds,
  • Kofi Agyapong Addo,
  • Samuel Ayetibo Ofori,
  • Charles Mensah Owusu,
  • Zakari Abdul-Karim,
  • Freddie Boateng Opoku

摘要

Introduction

Toxocariasis is one of the neglected parasitic infections globally. Exposure is highest where sanitation is poor and access to health care is limited. In Ghana, similar conditions exist in many rural and peri-urban communities. This study assessed the prevalence and determinants of toxocariasis in humans and dogs in Ghana.

Methods

A cross-sectional study was conducted in humans and dogs drawn from two regions of Ghana from January–October 2025. Human sera were tested for anti-Toxocara antibodies using serological assays, while faecal samples of dogs were analyzed using molecular methods.

Results

Human Toxocara seroprevalence was 14.5% (95% CI 11.4–17.5). Seropositivity was highest in children aged 6–15 years (23.9%, 95% CI 16.7–31.1) and lowest in the 16–30-year group (4.5%, 95% CI 0.6–8.3). Males (18.6%, 95% CI 13.9–23.3) and rural residents (27.5%, 95% CI 20.6–34.4) showed higher infection. Logistic regression showed that being male increased the odds of infection (AOR = 2.06; 95% CI 1.22–3.48), living in a rural area (AOR = 4.13; 95% CI 2.47–6.92) and having no formal education increased the likelihood of infection. Among dogs, the overall prevalence was 56.1% (95% CI 51.4–60.7). T. canis was the dominant species (87.9%), while T. cati accounted for 12.1%. Young dogs were much less likely to be infected than puppies (AOR = 0.18; 95% CI 0.10–0.30). Foreign-breed dogs had lower odds of infection than local breeds (AOR = 0.26; 95% CI 0.10–0.68).

Conclusion

The study reports on the burden of Toxocara exposure in both humans and dog populations. Children, males, rural residents, and individuals with no education were identified as risk groups. In dogs, puppies and local-breeds were found to be key reservoirs, highlighting their role in transmission dynamics. The findings underscore the importance of dog deworming, hygiene education and other One Health approaches to reduce the risk of transmission. This study provides the first molecular evidence of Toxocara cati infections in dogs in Ghana, warranting further investigation into cross-species transmission dynamics.