Scholarlink

<p>Hepatocellular carcinoma (HCC) is often linked with various paraneoplastic syndromes; however, it is uncommon for these syndromes to present primarily as ataxia. This case report details a distinctive instance of HCC-induced paraneoplastic syndrome characterized by significant ataxia symptoms, thereby enriching the sparse literature on this atypical clinical presentation. The patient, a 66-year-old male, had been experiencing progressive gait instability and weakness in his left lower limb for a year, with a noticeable deterioration over the past month. His medical background included hypertension, diabetes, chronic hepatitis B, and a previous ischemic stroke. Initial neurological assessments and Brain MRI did not indicate any new brain lesions; however, there was a marked increase in alpha-fetoprotein (AFP) levels, and Upper Abdominal MRI results pointed towards a hepatic tumor. Following these findings, he was diagnosed with HCC. The patient underwent surgical resection of the liver tumor, and histopathological analysis confirmed the diagnosis. After the surgery, his AFP levels returned to normal, and there was a significant improvement in his neurological symptoms, including ataxia. This case underscores a rare manifestation of HCC-induced paraneoplastic syndrome primarily presenting as ataxia. The notable alleviation of the patient’s neurological symptoms post-surgery highlights the necessity of considering paraneoplastic syndromes in patients exhibiting unexplained neurological issues alongside underlying malignancies. This report contributes to the limited documentation of HCC cases presenting predominantly with ataxia and stresses the importance of a comprehensive diagnostic strategy in similar clinical situations. Over the past four years, the patient experienced recurrent neurological symptoms coinciding with the recurrence of hepatocellular carcinoma; however, these symptoms resolved following transarterial chemoembolization (TACE) treatment. This observation supports the conclusion that the patient’s neurological symptoms were attributable to a neurologic paraneoplastic syndrome associated with liver cancer.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Ataxia as a paraneoplastic syndrome in hepatocellular carcinoma: a case report and literature review

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月11日

查看全文
  • Shicai Liang,
  • Yimin Liu,
  • Xusheng Zhang,
  • Xuebo Wang,
  • Long Chen,
  • Junzhi Leng,
  • Haining Li,
  • Bendong Chen

摘要

Hepatocellular carcinoma (HCC) is often linked with various paraneoplastic syndromes; however, it is uncommon for these syndromes to present primarily as ataxia. This case report details a distinctive instance of HCC-induced paraneoplastic syndrome characterized by significant ataxia symptoms, thereby enriching the sparse literature on this atypical clinical presentation. The patient, a 66-year-old male, had been experiencing progressive gait instability and weakness in his left lower limb for a year, with a noticeable deterioration over the past month. His medical background included hypertension, diabetes, chronic hepatitis B, and a previous ischemic stroke. Initial neurological assessments and Brain MRI did not indicate any new brain lesions; however, there was a marked increase in alpha-fetoprotein (AFP) levels, and Upper Abdominal MRI results pointed towards a hepatic tumor. Following these findings, he was diagnosed with HCC. The patient underwent surgical resection of the liver tumor, and histopathological analysis confirmed the diagnosis. After the surgery, his AFP levels returned to normal, and there was a significant improvement in his neurological symptoms, including ataxia. This case underscores a rare manifestation of HCC-induced paraneoplastic syndrome primarily presenting as ataxia. The notable alleviation of the patient’s neurological symptoms post-surgery highlights the necessity of considering paraneoplastic syndromes in patients exhibiting unexplained neurological issues alongside underlying malignancies. This report contributes to the limited documentation of HCC cases presenting predominantly with ataxia and stresses the importance of a comprehensive diagnostic strategy in similar clinical situations. Over the past four years, the patient experienced recurrent neurological symptoms coinciding with the recurrence of hepatocellular carcinoma; however, these symptoms resolved following transarterial chemoembolization (TACE) treatment. This observation supports the conclusion that the patient’s neurological symptoms were attributable to a neurologic paraneoplastic syndrome associated with liver cancer.