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Background <p>Radiation-induced xerostomia is a prevalent and incapacitating side effect among patients with head and neck cancer (HNC), significantly impacting swallowing, sleep, nutritional status, and quality of life (QoL).</p> Aim <p>This review assessed the burden of radiation-induced xerostomia and its consequences for swallowing disturbances, nutritional status, sleep quality, and QoL in patients with HNC undergoing radiotherapy.</p> Method <p>An updated synthesis of current evidence was conducted using the Population, Intervention, Comparison, Outcome, and Time (PICOT) framework to analyze relevant studies. Eligible studies published between 2019 and 2024 were identified through systematic searches of PubMed, MEDLINE, CINAHL, and Scopus. Inclusion criteria focused on adult HNC patients undergoing radiation therapy, with outcomes assessing xerostomia, swallowing disturbance, nutritional status, sleep disturbances, or QoL. Data from 37 studies involving 6118 patients were extracted, including study design, patient demographics, treatment specifics, and outcome measures.</p> Data synthesis <p>Findings revealed that xerostomia significantly affects swallowing, sleep, and nutritional status, leading to QoL impairments. Advanced radiotherapy techniques, such as intensity-modulated radiation therapy, were associated with reduced xerostomia severity.</p> Conclusion <p>Radiation-induced xerostomia profoundly impacts the well-being of HNC patients. Interventions targeting symptom management, advanced treatment modalities, and supportive care strategies are critical to improving QoL and clinical outcomes. Further longitudinal research is needed to address knowledge gaps and optimize care.</p>

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Radiation-induced xerostomia in head and neck cancers: a comprehensive review for burden and impact on nutrition, sleep, and quality of life

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月2日

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  • Mohammad M. Alnaeem,
  • Sameera K. Darwish,
  • Abdulqadir J. Nashwan

摘要

Background

Radiation-induced xerostomia is a prevalent and incapacitating side effect among patients with head and neck cancer (HNC), significantly impacting swallowing, sleep, nutritional status, and quality of life (QoL).

Aim

This review assessed the burden of radiation-induced xerostomia and its consequences for swallowing disturbances, nutritional status, sleep quality, and QoL in patients with HNC undergoing radiotherapy.

Method

An updated synthesis of current evidence was conducted using the Population, Intervention, Comparison, Outcome, and Time (PICOT) framework to analyze relevant studies. Eligible studies published between 2019 and 2024 were identified through systematic searches of PubMed, MEDLINE, CINAHL, and Scopus. Inclusion criteria focused on adult HNC patients undergoing radiation therapy, with outcomes assessing xerostomia, swallowing disturbance, nutritional status, sleep disturbances, or QoL. Data from 37 studies involving 6118 patients were extracted, including study design, patient demographics, treatment specifics, and outcome measures.

Data synthesis

Findings revealed that xerostomia significantly affects swallowing, sleep, and nutritional status, leading to QoL impairments. Advanced radiotherapy techniques, such as intensity-modulated radiation therapy, were associated with reduced xerostomia severity.

Conclusion

Radiation-induced xerostomia profoundly impacts the well-being of HNC patients. Interventions targeting symptom management, advanced treatment modalities, and supportive care strategies are critical to improving QoL and clinical outcomes. Further longitudinal research is needed to address knowledge gaps and optimize care.