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Background <p>Acute respiratory distress syndrome (ARDS) is a critical condition marked by severe alveolar damage and oxygenation impairment, leading to high mortality rates despite treatment with mechanical ventilation and fluid management. Halotherapy, a non-invasive treatment initially used for chronic respiratory diseases like COPD and asthma, has yet to be fully explored for its efficacy in ARDS.</p> Methods <p>This interventional study involved 97 patients with ARDS, who were divided into a halotherapy treatment group and a standard treatment group. The study collected data through electronic medical records, laboratory tests, and direct patient assessments to evaluate biomarkers, lung function, and clinical outcomes before and after treatment.</p> Results <p>Compared to standard treatment group, halotherapy significantly reduced levels of NLRP3, IL-1β, Caspase-1, and MMP3. Lung function enhancements included increases in FVC and FEV1. Additionally, the incidence of major adverse cardiac events and renal dysfunction decreased significantly in the halotherapy group, highlighting halotherapy's potential to improve clinical outcomes in ARDS treatment.</p> Conclusions <p>Halotherapy, with its anti-inflammatory and antibacterial properties, provides an effective treatment option for ARDS patients. Its non-invasive nature and good tolerability make it a promising adjunctive therapy for managing ARDS and potentially other respiratory diseases.</p>

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Halotherapy improves the prognosis of acute respiratory distress syndrome and alleviated pyroptosis related biomarkers

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月10日

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  • Wenhui Xu,
  • Zhendong Cao,
  • Li Wang,
  • Baoju Huang,
  • Yimin Zhu,
  • Lei Li

摘要

Background

Acute respiratory distress syndrome (ARDS) is a critical condition marked by severe alveolar damage and oxygenation impairment, leading to high mortality rates despite treatment with mechanical ventilation and fluid management. Halotherapy, a non-invasive treatment initially used for chronic respiratory diseases like COPD and asthma, has yet to be fully explored for its efficacy in ARDS.

Methods

This interventional study involved 97 patients with ARDS, who were divided into a halotherapy treatment group and a standard treatment group. The study collected data through electronic medical records, laboratory tests, and direct patient assessments to evaluate biomarkers, lung function, and clinical outcomes before and after treatment.

Results

Compared to standard treatment group, halotherapy significantly reduced levels of NLRP3, IL-1β, Caspase-1, and MMP3. Lung function enhancements included increases in FVC and FEV1. Additionally, the incidence of major adverse cardiac events and renal dysfunction decreased significantly in the halotherapy group, highlighting halotherapy's potential to improve clinical outcomes in ARDS treatment.

Conclusions

Halotherapy, with its anti-inflammatory and antibacterial properties, provides an effective treatment option for ARDS patients. Its non-invasive nature and good tolerability make it a promising adjunctive therapy for managing ARDS and potentially other respiratory diseases.