Scholarlink

<p>Long-stranded noncoding RNAs (lncRNAs) are a group of RNAs that are longer than 200 nucleotides and without protein-coding ability. Current researches indicated that the dysregulated expression of lncRNAs not only impaired normal cell growth and development, but also interfered with the cell cycle and cellular metabolism, thereby causing the development of various diseases. LncRNA ADAMTS9-AS1 is an antisense lncRNA produced by reversing transcription of ADAMTS9-AS1. LncRNA ADAMTS9-AS1 is closely related to different types of diseases. In addition to its own aberrant expression, it could also act as a miRNA sponge and competitively bind to miRNAs to participate in the process of disease occurrence through complex pathways and interactions with other genes and proteins. Therefore, this paper reviews the specific mechanism of lncRNA ADAMTS9-AS1 in different diseases, which promises to be a new biomarker and therapeutic target for a variety of diseases.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Regulation of different types of diseases by lncRNA ADAMTS9-AS1

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月16日

查看全文
  • Junyu He,
  • Jie Liu,
  • Ying Zhang,
  • Mengqiong Shi,
  • Chengfu Yuan,
  • Jie Xu,
  • Haoran Li,
  • Jihong Zhang,
  • Haiming Tang

摘要

Long-stranded noncoding RNAs (lncRNAs) are a group of RNAs that are longer than 200 nucleotides and without protein-coding ability. Current researches indicated that the dysregulated expression of lncRNAs not only impaired normal cell growth and development, but also interfered with the cell cycle and cellular metabolism, thereby causing the development of various diseases. LncRNA ADAMTS9-AS1 is an antisense lncRNA produced by reversing transcription of ADAMTS9-AS1. LncRNA ADAMTS9-AS1 is closely related to different types of diseases. In addition to its own aberrant expression, it could also act as a miRNA sponge and competitively bind to miRNAs to participate in the process of disease occurrence through complex pathways and interactions with other genes and proteins. Therefore, this paper reviews the specific mechanism of lncRNA ADAMTS9-AS1 in different diseases, which promises to be a new biomarker and therapeutic target for a variety of diseases.