Background <p>The risk of immunodeficiency associated with frequent messenger ribonucleic acid (mRNA) vaccinations has become increasingly evident, leading to the widespread discontinuation of additional doses, except in Japan.</p> Main body <p>Reevaluation of vaccination programs, including live-attenuated vaccines, is crucial. Recently, three cases of children who died a day after routine vaccination were reported in Japan. Despite detailed information, including autopsy findings, experts concluded that a causal relationship with vaccination could not be evaluated. This commentary highlights the challenges with mRNA vaccines and further discusses the need to reassess the efficacy and safety of vaccines that have already been approved.</p> Conclusion <p>In the post-mRNA vaccination era, marked by an increase in shingles cases, it is essential to re-evaluate the risks and benefits of currently approved vaccines.</p>