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Acute promyelocytic leukemia: the first reported case diagnosed by immunophenotyping in Mozambique

  • Edson Mongo,
  • Felismina Matola,
  • Adérito Sigaúque,
  • Vânia Monteiro,
  • Onélia Guiliche,
  • Teresa Babetine,
  • Lena Manhique-Coutinho,
  • Juliana Mutchamua,
  • Angelina Dias,
  • Dadirayi Mutsaka,
  • Tom Decroo,
  • Tinne Gils,
  • Chishamiso Mudenyanga,
  • Faizana Amodo,
  • Eugênia Terra-Granado,
  • Raquel Matavele Chissumba

摘要

Patients with acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML), often present with severe leucocytosis and thrombocytopenia, which may lead to symptoms that require prompt diagnosis and treatment. Immunophenotyping combined with cytomorphology is a valuable tool for identifying APL patients. We describe the case of a 9-year-old male patient who was diagnosed with APL in July 2022 using immunophenotyping combined with cytomorphology. The patient was treated with chemotherapy and is now in full remission in the maintenance phase. This case demonstrated the importance of timely differential diagnosis using the correct tools, allowing inclusion in the appropriate treatment protocol.