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<p>Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory rheumatic disease in children and adolescents. Early symptoms such as morning joint stiffness, compensatory posture and reduced physical performance are present from the earliest years of life but are often not recognized until later in clinical practice. A&#xa0;delayed diagnosis can, however, lead to irreversible joint damage, growth disorders and extra-articular complications such as uveitis. Following diagnosis, the use of the ‘treat-to-target’ approach, involving the targeted use of medication—including, increasingly, biologic therapies—has led to a&#xa0;significant improvement in the quality of life of the children and adolescents affected. This article outlines the distinctive features of JIA in comparison with the differential diagnosis of other inflammatory joint diseases, the structured approach to be followed for suspected JIA, the use of immunosuppressants in general practice, and the transition to adult care where ongoing treatment for JIA is required. Early diagnosis is paramount, as it is the only way for new treatment approaches to achieve their full effectiveness.</p>

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Juvenile idiopathische Arthritis

  • 期刊论文

  • 发表日期：

    2026年5月12日

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  • Andreas Wörner

摘要

Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory rheumatic disease in children and adolescents. Early symptoms such as morning joint stiffness, compensatory posture and reduced physical performance are present from the earliest years of life but are often not recognized until later in clinical practice. A delayed diagnosis can, however, lead to irreversible joint damage, growth disorders and extra-articular complications such as uveitis. Following diagnosis, the use of the ‘treat-to-target’ approach, involving the targeted use of medication—including, increasingly, biologic therapies—has led to a significant improvement in the quality of life of the children and adolescents affected. This article outlines the distinctive features of JIA in comparison with the differential diagnosis of other inflammatory joint diseases, the structured approach to be followed for suspected JIA, the use of immunosuppressants in general practice, and the transition to adult care where ongoing treatment for JIA is required. Early diagnosis is paramount, as it is the only way for new treatment approaches to achieve their full effectiveness.