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Purpose <p>Prevention of vascular events is the main objective in patients with polycythemia vera (PV) or essential thrombocythemia (ET). Carotid ultrasonography (USG) is a safe and noninvasive diagnostic tool that can be used to stratify cardiovascular and stroke risks. In our previous study, carotid plaque burden was significantly higher in patients with PV/ET than in the general population. This study aimed to determine changes in carotid plaques in patients with PV/ET.</p> Methods <p>We retrospectively evaluated the medical records of patients with ET/PV who had undergone carotid USG at least twice.</p> Results <p>Of the 56 patients, 30 had PV and 26 had ET. The carotid plaque score was increased in the follow-up carotid USG compared with that in the initial carotid USG (3.38 ± 1.47 vs. 3.73 ± 1.46, <i>p</i> = 0.0139). The carotid plaque burden at the time of follow-up carotid USG showed no significant differences in patients with a complete hematologic response (CHR); however, it significantly worsened in patients who failed to achieve CHR.</p> Conclusion <p>We confirmed that the carotid plaque burden persisted during follow-up in patients with PV/ET. A CHR may prevent an increase in carotid plaque burden.</p>

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Progression of carotid plaque burden in patients with polycythemia vera and essential thrombocythemia

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月1日

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  • Seong Soon Kwon,
  • Sun Young Jeong,
  • Min-Young Lee,
  • Kyoung Ha Kim,
  • Namsu Lee,
  • Jong-Ho Won,
  • Seug Yun Yoon

摘要

Purpose

Prevention of vascular events is the main objective in patients with polycythemia vera (PV) or essential thrombocythemia (ET). Carotid ultrasonography (USG) is a safe and noninvasive diagnostic tool that can be used to stratify cardiovascular and stroke risks. In our previous study, carotid plaque burden was significantly higher in patients with PV/ET than in the general population. This study aimed to determine changes in carotid plaques in patients with PV/ET.

Methods

We retrospectively evaluated the medical records of patients with ET/PV who had undergone carotid USG at least twice.

Results

Of the 56 patients, 30 had PV and 26 had ET. The carotid plaque score was increased in the follow-up carotid USG compared with that in the initial carotid USG (3.38 ± 1.47 vs. 3.73 ± 1.46, p = 0.0139). The carotid plaque burden at the time of follow-up carotid USG showed no significant differences in patients with a complete hematologic response (CHR); however, it significantly worsened in patients who failed to achieve CHR.

Conclusion

We confirmed that the carotid plaque burden persisted during follow-up in patients with PV/ET. A CHR may prevent an increase in carotid plaque burden.