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Purpose <p>Plasmablastic lymphoma (PBL) is a rare, aggressive lymphoma that is characterized by terminal B-cell differentiation. In the West, PBL usually occurs in patients with immunodeficiencies, particularly those induced by human immunodeficiency virus (HIV) infection. We investigated the clinicopathological features of PBL at a single institute in Taiwan, where HIV infection is rare.</p> Methods <p>This retrospective chart review identified PBL cases that were treated at a single institute in southern Taiwan between 2008 and 2024.</p> Results <p>We identified nine patients (four males and five females; median age 71&#xa0;years). Of the eight patients tested for HIV, only one tested positive. Pathologically, the tumors showed plasmablastic morphology and immunophenotype, and three (33%) cases tested positive for Epstein–Barr virus. Six (67%) patients presented with Stage IV disease, including five (56%) with malignant effusion. Six patients were treated with chemotherapy and the remaining three received only supportive care. During a median follow-up of 10&#xa0;months, five patients died of progressive disease, two died of unrelated diseases, and two were alive with PBL relapse.</p> Conclusion <p>In Taiwan, PBL constitutes a rare and aggressive clinical condition and is frequently associated with malignant effusion. In contrast to Western patients, the PBL in most patients from Taiwan was unrelated to HIV infection.</p>

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Frequent association of malignant effusions in plasmablastic lymphoma: a single-institutional experience of nine cases in Taiwan

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月7日

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  • Bo-Jung Chen,
  • Yu-Ting Kuo,
  • Sheng-Tsung Chang,
  • Khin-Than Win,
  • Shang-Wen Chen,
  • Sheng-Yen Hsiao,
  • Yin-Hsun Feng,
  • Yen-Chuan Hsieh,
  • Shih-Sung Chuang

摘要

Purpose

Plasmablastic lymphoma (PBL) is a rare, aggressive lymphoma that is characterized by terminal B-cell differentiation. In the West, PBL usually occurs in patients with immunodeficiencies, particularly those induced by human immunodeficiency virus (HIV) infection. We investigated the clinicopathological features of PBL at a single institute in Taiwan, where HIV infection is rare.

Methods

This retrospective chart review identified PBL cases that were treated at a single institute in southern Taiwan between 2008 and 2024.

Results

We identified nine patients (four males and five females; median age 71 years). Of the eight patients tested for HIV, only one tested positive. Pathologically, the tumors showed plasmablastic morphology and immunophenotype, and three (33%) cases tested positive for Epstein–Barr virus. Six (67%) patients presented with Stage IV disease, including five (56%) with malignant effusion. Six patients were treated with chemotherapy and the remaining three received only supportive care. During a median follow-up of 10 months, five patients died of progressive disease, two died of unrelated diseases, and two were alive with PBL relapse.

Conclusion

In Taiwan, PBL constitutes a rare and aggressive clinical condition and is frequently associated with malignant effusion. In contrast to Western patients, the PBL in most patients from Taiwan was unrelated to HIV infection.