<p>For the past few decades, the healthcare sector has utilised smart devices, including e-textiles, for enhanced healthcare delivery. E-textiles have been identified as suitable materials for wearable biomedical devices due to their good compatibility, flexibility, comfort, and lightweight properties. Following the discovery of wearable e-textiles in the 1960s, significant improvements have been made in the field, thanks to cutting-edge research from scholars worldwide. Given the significant progress made in the e-textile field, a comprehensive assessment of its current state remains essential to support future scholars by identifying promising directions for further investigation. This comprehensive review accounts for the new materials, techniques, and technologies adopted for e-textiles manufacturing for healthcare delivery. It also investigates advanced applications of e-textiles and the challenges involved in their widespread use. The study found that innovative fabrication/printing techniques and advanced materials such as carbon-based nanomaterials, conductive polymers, 2D transition metal compounds, metallic nanostructures, and hybrid/composite materials have contributed greatly to recent progress of the e-textile concept. Notwithstanding, the study found challenges, such as the high cost of fabrication, data privacy, sustainability issues, and scalability, persist. Further research on the exploration of innovative technologies that allow mass production of e-textiles, sustainable materials innovations, and enhanced security architecture that will ensure data privacy is imperative, as well as a global regulatory framework that will guide the full deployment of these technologies.</p>