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<p>This paper strives to contribute to the development of a low cost, compact, and portable colorimeter which finds its application in the diagnosis of hyper and hypo concentrations of urea in human blood. The proposed instrument consists of an LED as a light source that is Green(520–525&#xa0;nm) and a photodiode as a detector. This proposed device makes use of an emitter circuit, a detector circuit and an ATmega microcontroller to balance the wavelength and process data. The device has undergone substantial experimentation to reduce its weight and cost. The precision of this instrument has been calculated based on the linear regression model trained and a notable accuracy of 98.9% has been achieved which has thus enhanced the robustness of this model. This device has been repurposed as a serum urea analyzer for validation purposes but can be used for estimation of various end-point chemistries upon changing the color of the light source used. The calibration of our newly developed device was followed by rigorous testing of different blood samples. The urea values observed for specific samples, were compared with the concentrations of urea of the same samples obtained from NABL accredited laboratories, which resulted in a minimum absolute error of 0.101&#xa0;mg/dl and the average root mean square error came out to be 1.43&#xa0;mg/dl.</p>

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Computation of urea concentration in blood using a low cost autogenic colorimeter

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月23日

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  • Jishnu Bhadra,
  • Shaunak Roy,
  • Niladri Khamaru,
  • Prasun Chowdhury

摘要

This paper strives to contribute to the development of a low cost, compact, and portable colorimeter which finds its application in the diagnosis of hyper and hypo concentrations of urea in human blood. The proposed instrument consists of an LED as a light source that is Green(520–525 nm) and a photodiode as a detector. This proposed device makes use of an emitter circuit, a detector circuit and an ATmega microcontroller to balance the wavelength and process data. The device has undergone substantial experimentation to reduce its weight and cost. The precision of this instrument has been calculated based on the linear regression model trained and a notable accuracy of 98.9% has been achieved which has thus enhanced the robustness of this model. This device has been repurposed as a serum urea analyzer for validation purposes but can be used for estimation of various end-point chemistries upon changing the color of the light source used. The calibration of our newly developed device was followed by rigorous testing of different blood samples. The urea values observed for specific samples, were compared with the concentrations of urea of the same samples obtained from NABL accredited laboratories, which resulted in a minimum absolute error of 0.101 mg/dl and the average root mean square error came out to be 1.43 mg/dl.