<p>The aim of human-object interaction (HOI) detection is to identify the triplets consisting of a human, a verb, and an object. Although existing methods leverage vision-language models (e.g., CLIP) to transfer textual information for unseen compositions, they often fail to capture the fine-grained visual cues that are essential for complex interactions, such as spatial configurations and object affordances. In this paper, we introduce visual guidance as an alternative approach to achieving the desired outcome. We define a new visual-guided HOI detection task for the first time, aiming at detecting unseen HOI categories using a small number of guidance examples. To support this new task, we have constructed a new benchmark dataset, which contains one base set and four novel sets, taking into account the peculiarities of HOI. Then, we propose a VG-HOI model with progressive guidance, query reconstruction, and a conditional uncoupling decoder to supplement common HOI knowledge and task-specific cues to improve the generalization capability of our model. Besides, we explore a new guidance sampling strategy — disentangled guidance — for real-world scenarios. Our in-depth analysis of the experimental results shows that the proposed model can improve the ability to generalize when detecting visual-guided HOI.</p>