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Purpose <p>Emerging evidence suggests that retinal changes may indicate brain disorders. However, the association between retinal nerve fiber layer (RNFL) thickness and delirium risk has not been investigated. This study examined whether reduced RNFL thickness could predict an increased risk of delirium.</p> Methods <p>A total of 42,449 participants without a history of delirium were recruited from the UK Biobank. Optical coherence tomography (OCT) was used for RNFL thickness measurement. Cox proportional hazard models were applied to calculate hazard ratios and 95% confidence intervals for incident delirium risk.</p> Results <p>Over a median follow-up of 13.7 years, 1.0% of participants (425) developed delirium. Each 5-μm decrease in RNFL thickness was associated with a 13.6% higher hazard of delirium. The lowest RNFL tertile was linked to a 47.7% higher hazard compared to the highest tertile. A similar correlation was observed for postoperative delirium.</p> Conclusion <p>Reduced RNFL thickness is associated with increased delirium risk, highlighting the potential of OCT-based RNFL measurements as a non-invasive tool to identify potential delirium patients.</p>

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Retinal nerve fiber layer thinning as a predictor of delirium in medical and surgical patients: a prospective cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月11日

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  • Xiaoxiao Wang,
  • Xinning Mi,
  • Yichen Cui,
  • Jingshu Hong,
  • Zhuzhu Li,
  • Yimei Cai,
  • Xiangyang Guo,
  • Nan Li,
  • Zhengqian Li

摘要

Purpose

Emerging evidence suggests that retinal changes may indicate brain disorders. However, the association between retinal nerve fiber layer (RNFL) thickness and delirium risk has not been investigated. This study examined whether reduced RNFL thickness could predict an increased risk of delirium.

Methods

A total of 42,449 participants without a history of delirium were recruited from the UK Biobank. Optical coherence tomography (OCT) was used for RNFL thickness measurement. Cox proportional hazard models were applied to calculate hazard ratios and 95% confidence intervals for incident delirium risk.

Results

Over a median follow-up of 13.7 years, 1.0% of participants (425) developed delirium. Each 5-μm decrease in RNFL thickness was associated with a 13.6% higher hazard of delirium. The lowest RNFL tertile was linked to a 47.7% higher hazard compared to the highest tertile. A similar correlation was observed for postoperative delirium.

Conclusion

Reduced RNFL thickness is associated with increased delirium risk, highlighting the potential of OCT-based RNFL measurements as a non-invasive tool to identify potential delirium patients.