<p>Homelessness is a wicked multi-faceted problem without a single solution. An average of 235,000 people in Canada are homeless per year. The pervasive issue of homelessness demands innovative and holistic solutions. This article addresses the critical intersection of mental health and housing stability by exploring the impact of integrating virtual mental health services within Housing First Programs. The Housing First Program (HFP) prioritises stable housing for individuals experiencing homelessness and is identified as an effective tool against homelessness. However, mental health challenges hinder successful long-term housing stability for many HFP participants. The incorporation of evidence-based virtual mental health services (VMHS) into HFPs could accelerate homelessness prevention in Canada by addressing mental health challenges of HFP participants. This perspective article presents a conceptual framework for HFP–VMHS integration, focusing on suitability, infrastructure, digital health literacy, organizational capacity for equity, cultural appropriateness, and policy and regulation. Recommendations for successful integration based on this framework include comprehensive needs assessments, infrastructural development, collaborative case management, culturally competent care, continuous monitoring and evaluation, and funding and regulation. These recommendations guide the implementation and maximise the benefits of HFP–VMHS integration. The integration of VMHS into HFPs holds the potential to transform the approach to homelessness prevention in Canada. By addressing the intertwined challenges of mental health and housing instability, this integration can provide a more inclusive and effective system for vulnerable populations. The findings advocate for policy support, funding, and a focus on health equity to sustain and enhance this integration.</p>