Background <p>Effective clinical handover is a crucial aspect of safe patient care. However, handover is often carried out inadequately, which can have serious consequences for patient safety.</p> Purpose <p>The study aims to evaluate whether the implementation of a standardized tool, based on the ISBAR model, in an emergency department (ED), could enhance the completeness and accuracy of information exchanged during nursing handovers at shift changes.</p> Methods <p>This is a prospective observational cohort study conducted in an ED. A handover evaluation form (HEF) was used to assess the quality of nursing handovers during shift changes, both before and after the introduction of a standardized handover tool, referred to as the "handover framework", based on the ISBAR model.</p> Results <p>Following the introduction of the handover framework, the median value for nursing handover assessment score was 84.6% (IQR: 74.2%; 100.0%), which was significantly higher than the median score of 77.8% (IQR: 66.7%; 100.0%) observed before the framework's introduction (p &lt; 0.001). Additionally, all indicators of the HEF showed significant improvement after the implementation of the handover framework.</p> Conclusions <p>The results suggest that using a standardized tool, consistent with existing literature, can significantly improve nursing handovers in high-intensity, complex care settings. This approach may promote effective communication and the proper transfer of responsibility during shift changes, reducing the risk of information loss and potentially minimizing adverse patient outcomes.</p>