<p>Personalized treatment and prognosis improvement of sepsis remain one of the most challenging issues in critical care medicine. Whole blood cell-derived inflammatory markers have the potential to reflect the body’s inflammatory status, immune function, and changes in disease condition. This article discusses the significant importance of whole blood cell-derived inflammatory markers in the assessment and monitoring of sepsis patients’ conditions, calling for more attention to be paid to these markers. This attention will provide a solid basis for achieving early and precise diagnosis as well as personalized treatment stratification.</p>