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<p>Herein, for monitoring the carboxylesterase (CE) level on studying medicine-food homology samples, an isoflavone-based fluorescent probe, <b>IFone-CE</b>, was developed on the basis of the representative Formonetin and the extended saturated fatty acidic chain as the recognition group. A typical turning-on was established, which remained the modification potential. The probe <b>IFone-CE</b> suggested general advantages including a relatively rapid response, stable optical performance in various working conditions of pH, temperature, and storage. It also exhibited practical linear range, high sensitivity, high selectivity, and low cyto-toxicity. The solution system containing <b>IFone-CE</b> achieved monitoring the biological efficacy of medicine-food homology samples. In the confocal imaging, <b>IFone-CE</b> realized the reduction and promotion effect of the samples in living colorectal cells. This work raised beneficial insights for the effective utilization of resources and medicinal chemistry research.</p> Graphical abstract <p>An isoflavone-based fluorescent probe, <b>IFone-CE</b>, was developed for monitoring the carboxylesterase (CE) level on studying medicine-food homology samples. The design was on the basis of the representative Formonetin and the extended saturated fatty acidic chain as the recognition group. The probe <b>IFone-CE</b> suggested general advantages including a relatively rapid response, stable optical performance in various working conditions, practical linear range, high sensitivity, high selectivity, and low cyto-toxicity. <b>IFone-CE</b> achieved monitoring the biological efficacy of medicine-food homology samples and imaging in living colorectal cells.</p>

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Developing an isoflavone-based fluorescent probe for monitoring carboxylesterase on studying medicine-food homology samples

  • 期刊论文

  • 发表日期：

    2026年2月12日

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  • Juan Meng,
  • Yangyang Guo,
  • Fang Wang,
  • Yingmiao Lai,
  • Yingying Deng,
  • Hongcun Liu

摘要

Herein, for monitoring the carboxylesterase (CE) level on studying medicine-food homology samples, an isoflavone-based fluorescent probe, IFone-CE, was developed on the basis of the representative Formonetin and the extended saturated fatty acidic chain as the recognition group. A typical turning-on was established, which remained the modification potential. The probe IFone-CE suggested general advantages including a relatively rapid response, stable optical performance in various working conditions of pH, temperature, and storage. It also exhibited practical linear range, high sensitivity, high selectivity, and low cyto-toxicity. The solution system containing IFone-CE achieved monitoring the biological efficacy of medicine-food homology samples. In the confocal imaging, IFone-CE realized the reduction and promotion effect of the samples in living colorectal cells. This work raised beneficial insights for the effective utilization of resources and medicinal chemistry research.

Graphical abstract

An isoflavone-based fluorescent probe, IFone-CE, was developed for monitoring the carboxylesterase (CE) level on studying medicine-food homology samples. The design was on the basis of the representative Formonetin and the extended saturated fatty acidic chain as the recognition group. The probe IFone-CE suggested general advantages including a relatively rapid response, stable optical performance in various working conditions, practical linear range, high sensitivity, high selectivity, and low cyto-toxicity. IFone-CE achieved monitoring the biological efficacy of medicine-food homology samples and imaging in living colorectal cells.