Background <p>Care workers in long-term nursing homes often experience burdens and a high rate of resignations. This study aimed to investigate the mental health of care workers and to examine the relationship between the tendency to seek help and their mental health, through a comparison with the general population to address this issue.</p> Methods <p>Online surveys were conducted separately with 273 care workers and 260 general public using a questionnaire platform. They were asked about their demographic variables, mental health [the Kessler Psychological Distress Scale (K6) and stressors], help-seeking styles (self-directed, excessive, and avoidant help-seeking), and usage on use of psychological support services. The analyses were performed except for missing responses.</p> Results <p>Overall, 132 (48.4%) care workers scored higher than the cutoff point on the K6. Regarding stressors identified by the care workers, most of the contents were related to work-related matters and workplace relationships, as demonstrated through qualitative analysis. Hierarchical multiple regression analysis showed that the interaction term between each help-seeking style and participant group was non-significant. Meanwhile, age (<i>β</i> = −0.116, <i>p</i> = 0.009), excessive help-seeking (<i>β</i> = 0.120, <i>p</i> = 0.014), and avoidant help-seeking (<i>β</i> = 0.331, <i>p</i> &lt; 0.001) were associated with the K6.</p> Conclusion <p>This study revealed the tendency of care workers’ help-seeking behavior and its relationship to mental health. Improving care workers’ help-seeking skills and adjusting their work environment are essential for maintaining and enhancing their mental health.</p>