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Background <p>Sacha inchi (<i>Plukenetia volubilis</i>), a member of the Euphorbiaceae family, has long been valued for its nutritional and medicinal properties, including use in food and cosmetic industries as a poultice to soften, revitalize, and rejuvenate the skin. Its health benefits are attributed to its rich content of essential nutrients and phytocompounds.</p> Objective <p>This review systematically explores and compiles current scientific evidence on the efficacy of Sacha inchi.</p> Methods <p>Publications were identified and selected according to the PRISMA guidelines, with predetermined inclusion criteria. Databases searched included Web of Science, CENTRAL, LILACS, Scopus, PubMed®, and EBSCOhost.</p> Results <p>Thirteen articles were included, primarily using oil-based extracts or products, with treatment durations ranging from one month to 20&#xa0;months in human studies and 75&#xa0;min to 3.5&#xa0;months in animal studies. Clinical findings support the benefits of Sacha inchi for metabolic syndrome, cognitive enhancement, dry eye syndrome, and dermatological health, while animal studies suggest potential effects in managing hypertension, hyperlmia, and offering neuroprotection.</p> Conclusions <p>However, there remains a lack of comprehensive evaluation of specific formulations or extracts in both clinical and preclinical settings. Further research is needed, particularly regarding safety data at higher doses and for prolonged use.</p>

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Systematic review of preclinical and clinical evidence of Sacha inchi

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月29日

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  • Terence Yew Chin Tan,
  • Puteri Sofia Nadira Megat Kamaruddin,
  • Siti Hajar Muhamad Rosli,
  • Han Yin Lim,
  • Janice Sue Wen Chan,
  • Wan Ahmad Syazani Mohamed,
  • Puspawathy Krishnan,
  • Mohd Naeem Mohd Nawi,
  • Ida Farah Ahmad,
  • Nur Es Naini Awalludin,
  • Sophia Rasheeqa Ismail

摘要

Background

Sacha inchi (Plukenetia volubilis), a member of the Euphorbiaceae family, has long been valued for its nutritional and medicinal properties, including use in food and cosmetic industries as a poultice to soften, revitalize, and rejuvenate the skin. Its health benefits are attributed to its rich content of essential nutrients and phytocompounds.

Objective

This review systematically explores and compiles current scientific evidence on the efficacy of Sacha inchi.

Methods

Publications were identified and selected according to the PRISMA guidelines, with predetermined inclusion criteria. Databases searched included Web of Science, CENTRAL, LILACS, Scopus, PubMed®, and EBSCOhost.

Results

Thirteen articles were included, primarily using oil-based extracts or products, with treatment durations ranging from one month to 20 months in human studies and 75 min to 3.5 months in animal studies. Clinical findings support the benefits of Sacha inchi for metabolic syndrome, cognitive enhancement, dry eye syndrome, and dermatological health, while animal studies suggest potential effects in managing hypertension, hyperlmia, and offering neuroprotection.

Conclusions

However, there remains a lack of comprehensive evaluation of specific formulations or extracts in both clinical and preclinical settings. Further research is needed, particularly regarding safety data at higher doses and for prolonged use.