Background <p>Green tea (<i>Camellia sinesis</i>) has been studied extensively in adults living with obesity. The consumption of green tea has been investigated for body weight control, with or without exercise.</p> Objectives <p>This review aims to summarize the potential efficacy and safety of green tea in weight reduction.</p> Design <p>A systematic review was conducted in two databases PubMed And Web of Science to identify the relevant clinical studies published between 2016 And 2024. Randomized controlled trials and quasi-experimental studies that assessed the effect of green tea consumption on body weight control were included.</p> Results <p>Fourteen studies were identified. Three studies investigated the effect of green tea consumption without concurrent exercise. Meanwhile, eleven studies investigated the combined effect of green tea and exercise on body weight, body mass index (BMI), waist circumference and waist-hip ratio. Eleven studies (78.5%) showed that green tea supplementation is effective in reducing weight and BMI, with nine of them combined exercise. More research is warranted to standardize the dosage and duration of interventions. A few cases of mild gastric discomfort were reported in two studies. According to tertiary databases (Natural medicines and Lexicomp), several potential drug interactions with green tea have been identified. The interactions are dose-related, though an exact upper and lower threshold of green tea dosage are lacking.</p> Conclusions <p>The majority of clinical studies shown that green tea can lower body weight and BMI in adults with obesity, in particular combined with regular exercise. Green tea is generally safe, though hepatotoxicity has been reported in a dose and duration-dependent manner following consumption of concentrated green tea extracts. It is recommended to consult healthcare professionals prior as green tea may interact with other commonly used Western medications.</p>