<p>Over the past few decades, evidence-based medicine (EBM) has revolutionized medical practice by shifting clinical decision-making from empiricism and authoritative opinion to scientific research evidence. However, as medicine continues to evolve, increasing attention has been drawn to the limitations of relying solely on "evidence"—mechanistically sound yet clinically ineffective outcomes, statistically significant results that lack practical relevance, and a prevailing pattern of "logical clarity" coupled with "therapeutic distance." This overemphasis on research evidence, at the expense of clinical experience and patient values, has resulted in a dual dilemma of "evidence worship" and "humanistic deficiency" in medical practice. In this context, the concept of evidence-informed medicine (EIM), proposed by Professor Daiming Fan, offers a fresh perspective for transforming the paradigm of clinical medicine. This paper begins by examining the theoretical limitations and practical challenges of EBM, then analyzes the background and core philosophy of EIM, and finally proposes a practice framework that integrates both Evidence-Based and Evidence-Informed approaches—envisioning its profound implications for the future development of medicine.</p>