Scholarlink

<p>Mangrove ecosystems, particularly <i>Rhizophora apiculata</i>, are rich sources of bioactive phytochemicals with promising biomedical applications. In this study, a green synthesis approach was used to develop a chitosan-based nanoscaffold incorporating <i>R. apiculata</i> leaf extract was synthesized and characterized for structural, chemical, and biocompatibility properties. Phytochemical screening revealed flavonoids, tannins, glycosides, saponins, and phenolic compounds, with a total phenolic content (TPC) of 2.56 ± 0.4&#xa0;mg GAE/g. UV–Visible and FTIR analyses confirmed successful incorporation of bioactive metabolites, highlighting hydroxyl, carbonyl, and ether functional groups as key contributors to nanoparticle reduction and capping. SEM analysis demonstrated a highly porous, interconnected architecture across macro-, micro-, and nanoscale dimensions. EDS confirmed a carbon-rich matrix (C 80.3%, O 16.8%) with trace P, S, and Cl, while XRD revealed a predominantly amorphous structure with nanoscale crystallites. Zeta potential (+ 40&#xa0;mV) indicated strong positive surface charge and colloidal stability. Biocompatibility assessment using <i>Xiphophorus maculatus</i> survival assays showed a dose and time dependent, with minimal toxicity at lower concentrations. These results indicate that the <i>Rhizophora apiculata</i>–mediated nanoscaffold exhibits good structural integrity, bioactive functionality, and low acute toxicity, suggesting its potential suitability for biomedical applications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Development of a Chitosan-Based Nanoscaffold Incorporating Rhizophora apiculata Extract and Acute Toxicity Assessment in the Ornamental Fish Xiphophorus maculatus

  • 期刊论文

  • 发表日期：

    2026年7月16日

查看全文
  • Pavithra Thiraviyam,
  • Kaviya selvaraj,
  • Pauline Christupaul Roseline,
  • Dhanraj Ganapathy,
  • Pitchiah Sivaperumal

摘要

Mangrove ecosystems, particularly Rhizophora apiculata, are rich sources of bioactive phytochemicals with promising biomedical applications. In this study, a green synthesis approach was used to develop a chitosan-based nanoscaffold incorporating R. apiculata leaf extract was synthesized and characterized for structural, chemical, and biocompatibility properties. Phytochemical screening revealed flavonoids, tannins, glycosides, saponins, and phenolic compounds, with a total phenolic content (TPC) of 2.56 ± 0.4 mg GAE/g. UV–Visible and FTIR analyses confirmed successful incorporation of bioactive metabolites, highlighting hydroxyl, carbonyl, and ether functional groups as key contributors to nanoparticle reduction and capping. SEM analysis demonstrated a highly porous, interconnected architecture across macro-, micro-, and nanoscale dimensions. EDS confirmed a carbon-rich matrix (C 80.3%, O 16.8%) with trace P, S, and Cl, while XRD revealed a predominantly amorphous structure with nanoscale crystallites. Zeta potential (+ 40 mV) indicated strong positive surface charge and colloidal stability. Biocompatibility assessment using Xiphophorus maculatus survival assays showed a dose and time dependent, with minimal toxicity at lower concentrations. These results indicate that the Rhizophora apiculata–mediated nanoscaffold exhibits good structural integrity, bioactive functionality, and low acute toxicity, suggesting its potential suitability for biomedical applications.