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<p>This study reports titanium dioxide nanoparticles (TiO<sub>2</sub>NPs) biosynthesized from <i>Canarium asperum</i> L. plant leaf extract. The biosynthesized TiO<sub>2</sub>NPs were characterized by multiple techniques, including UV-visible spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Field emission scanning electron microscope (FE-SEM), Energy-dispersive X-ray spectroscopy (EDX), High resolution transmission electron microscopy (HR-TEM), and Gas chromatography mass spectrometry (GC-MS). The UV-visible spectroscopy analysis showed a strong absorption peak at 290&#xa0;nm, indicating the characteristic optical properties of TiO<sub>2</sub>NPs. XRD patterns confirmed the crystalline nature of the nanoparticles, while FT-IR spectroscopy revealed the presence of phytochemicals that functioned as both reducing and capping agents. The FE-SEM and HR-TEM demonstrated spherical morphology with particle sizes average ranging from 20 to 60&#xa0;nm, and EDX analysis confirmed the elemental composition. The biosynesized TiO<sub>2</sub>NPs exhibited potencial antibacterial activity, and the highest zone inhibition against <i>Escherichia coli</i> (8.1 ± 0.24&#xa0;mm) was observed. TiO<sub>2</sub>NPs exhibited a dose-dependent cytotoxic effect on human liver cancer (HepG2) cells, with an IC<sub>50</sub> value of 36.39&#xa0;µg/mL, indicating strong potential for anticancer therapy. Additionally, the photocatalytic degradation potential of the TiO<sub>2</sub>NPs was assessed using Rhodamine B dyes. The degradation efficiency was higher for Rhodamine B (89%) after 120&#xa0;min of visible light irradiation in <i>C. asperum-mediated</i> TiO<sub>2</sub>NPs. Overall, the biosynthesis approach for TiO<sub>2</sub>NPs is cost-effective and eco-friendly, with promising antibacterial, anticancer, and photocatalytic degradation properties. The study also highlights the current investigation in <i>C. asperum</i> leaf extract-mediated TiO<sub>2</sub>NPs and explores prospects in this emerging field of environmental remediation and nanomedicine.</p>

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Enhanced Antibacterial, Anticancer and Photocatalytic Activity of Biosynthesized Titanium Dioxide Nanoparticles (TiO2NPs) Using Canarium asperum Plant Leaf Extract

  • 期刊论文

  • 发表日期：

    2026年5月27日

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  • Chakkawan Boonwan,
  • Kumar Manimaran,
  • Gayathri Segaran,
  • Ranjith Rajendran,
  • Orawan Rojviroon,
  • Kaokanya Sudpraserat,
  • Nat Kasayapanand,
  • Roongrojana Songprakorp

摘要

This study reports titanium dioxide nanoparticles (TiO2NPs) biosynthesized from Canarium asperum L. plant leaf extract. The biosynthesized TiO2NPs were characterized by multiple techniques, including UV-visible spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Field emission scanning electron microscope (FE-SEM), Energy-dispersive X-ray spectroscopy (EDX), High resolution transmission electron microscopy (HR-TEM), and Gas chromatography mass spectrometry (GC-MS). The UV-visible spectroscopy analysis showed a strong absorption peak at 290 nm, indicating the characteristic optical properties of TiO2NPs. XRD patterns confirmed the crystalline nature of the nanoparticles, while FT-IR spectroscopy revealed the presence of phytochemicals that functioned as both reducing and capping agents. The FE-SEM and HR-TEM demonstrated spherical morphology with particle sizes average ranging from 20 to 60 nm, and EDX analysis confirmed the elemental composition. The biosynesized TiO2NPs exhibited potencial antibacterial activity, and the highest zone inhibition against Escherichia coli (8.1 ± 0.24 mm) was observed. TiO2NPs exhibited a dose-dependent cytotoxic effect on human liver cancer (HepG2) cells, with an IC50 value of 36.39 µg/mL, indicating strong potential for anticancer therapy. Additionally, the photocatalytic degradation potential of the TiO2NPs was assessed using Rhodamine B dyes. The degradation efficiency was higher for Rhodamine B (89%) after 120 min of visible light irradiation in C. asperum-mediated TiO2NPs. Overall, the biosynthesis approach for TiO2NPs is cost-effective and eco-friendly, with promising antibacterial, anticancer, and photocatalytic degradation properties. The study also highlights the current investigation in C. asperum leaf extract-mediated TiO2NPs and explores prospects in this emerging field of environmental remediation and nanomedicine.