Scholarlink

<p>Today, a wide range of biological applications depend on nanoparticles as small as 100&#xa0;nm. In this study, zinc oxide nanorods were successfully produced using the fungus <i>Aspergillus niger</i> culture filtrate (<i>A. niger</i>). UV-visible absorption spectroscopy showed an absorption peak at 270&#xa0;nm, indicating the formation of zinc oxide nanorods. Fourier Transform Infrared Spectroscopy (FTIR) study revealed that O-H bonds of phenols, alcohols, and aromatic primary amines are associated with zinc oxide nanorods. The SEM analysis showed almost spherical topology of the synthesized nanorods. However, Transmission Electron Microscopy (TEM) reveals that the nanoparticles are rod-like and range in size from 16 to 21&#xa0;nm. Zinc and oxygen were detected by energy-dispersive X-ray spectroscopy (EDS). Thermogravimetric analysis (TGA) confirms weight loss between 30 and 900&#xa0;°C with 7.730, 39.242, 17.982, and 25.089%. Zinc oxide nanorods effectively inhibit the growth of bacterial pathogens; however, among the pathogens tested, <i>Staphylococcus aureus</i> showed the largest inhibition zone (17&#xa0;mm). The HepG2 cells treated with these nanorods showed a remarkable 78.61% increase in glucose uptake compared to the standard control, as measured by NBDG uptake. Additionally, after 48&#xa0;h of incubation, these zinc oxide nanorods showed good wound-healing in L929 skin fibroblast cells, achieving 99.93% wound closure. Also, the chick chorioallantoic membrane (CAM) assay confirmed that these nanorods enhance angiogenesis. Based on the observed results, these zinc oxide nanorods could be used in the biomedical and pharmaceutical applications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Biogenic Zinc Oxide Nanorods with Potent Antibacterial, Wound Healing, and Antidiabetic Applications Via NBDG Uptake in HepG2 Cells

  • 期刊论文

  • 发表日期：

    2026年5月27日

查看全文
  • Ohoud A. Jefri,
  • Nur Anis Saherra Binti Abd Razak,
  • Shahnaz Majeed,
  • Mohammed Danish,
  • Ravindran Muthukumarasamy,
  • Abdulaziz M. Alanazi,
  • Mohammed Tahir Ansari

摘要

Today, a wide range of biological applications depend on nanoparticles as small as 100 nm. In this study, zinc oxide nanorods were successfully produced using the fungus Aspergillus niger culture filtrate (A. niger). UV-visible absorption spectroscopy showed an absorption peak at 270 nm, indicating the formation of zinc oxide nanorods. Fourier Transform Infrared Spectroscopy (FTIR) study revealed that O-H bonds of phenols, alcohols, and aromatic primary amines are associated with zinc oxide nanorods. The SEM analysis showed almost spherical topology of the synthesized nanorods. However, Transmission Electron Microscopy (TEM) reveals that the nanoparticles are rod-like and range in size from 16 to 21 nm. Zinc and oxygen were detected by energy-dispersive X-ray spectroscopy (EDS). Thermogravimetric analysis (TGA) confirms weight loss between 30 and 900 °C with 7.730, 39.242, 17.982, and 25.089%. Zinc oxide nanorods effectively inhibit the growth of bacterial pathogens; however, among the pathogens tested, Staphylococcus aureus showed the largest inhibition zone (17 mm). The HepG2 cells treated with these nanorods showed a remarkable 78.61% increase in glucose uptake compared to the standard control, as measured by NBDG uptake. Additionally, after 48 h of incubation, these zinc oxide nanorods showed good wound-healing in L929 skin fibroblast cells, achieving 99.93% wound closure. Also, the chick chorioallantoic membrane (CAM) assay confirmed that these nanorods enhance angiogenesis. Based on the observed results, these zinc oxide nanorods could be used in the biomedical and pharmaceutical applications.