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<p>Thyme oil, known for its antibacterial and anticancer potential, is frequently constrained by its low water solubility and high volatility. The present study aimed to fabricated and characterized the thyme oil loaded iron oxide nanoparticles topical gel (TYO-FeONPs) and its gel were scrutinized against cytotoxic and antibacterial activity. The physicochemical features of the TYO-FeONPs and gel were characterised using analytical instrument. GC-MS study exhibited the presence of thymol, carvacrol, ρ-Methyl salicylate, p-Cymene-2,5-diol, Caryophyllene, Camphor and etc. in the oil. FE-SEM spectroscopy showed the dispersed the particle of TYO-FeONPs in clusters form with good drug encapsulation of 76.4 ± 3.127%, higher drug release and zone of inhibition against <i>P. Aeruginosa</i> and <i>Bacillus subtilis</i>. HaCaT cell lines were chosen to assess the cytotoxicity of TYO-FeONPs gel with good cell viability result. This work emphasises the promise of TYO-FeONPs gel as a dual-purpose therapeutic agent for dermal use as antibacterial and cytotoxic agent.</p> Graphical Abstract <p></p>

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Fabrication and Characterization of Iron Oxide Nanoparticles Functionalised Thyme Oil Topical Gel for Antibacterial and Cytotoxic Activity

  • 期刊论文

  • 发表日期：

    2026年5月27日

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  • Abhayjeet Singh,
  • Amita Verma,
  • Deepika Singh

摘要

Thyme oil, known for its antibacterial and anticancer potential, is frequently constrained by its low water solubility and high volatility. The present study aimed to fabricated and characterized the thyme oil loaded iron oxide nanoparticles topical gel (TYO-FeONPs) and its gel were scrutinized against cytotoxic and antibacterial activity. The physicochemical features of the TYO-FeONPs and gel were characterised using analytical instrument. GC-MS study exhibited the presence of thymol, carvacrol, ρ-Methyl salicylate, p-Cymene-2,5-diol, Caryophyllene, Camphor and etc. in the oil. FE-SEM spectroscopy showed the dispersed the particle of TYO-FeONPs in clusters form with good drug encapsulation of 76.4 ± 3.127%, higher drug release and zone of inhibition against P. Aeruginosa and Bacillus subtilis. HaCaT cell lines were chosen to assess the cytotoxicity of TYO-FeONPs gel with good cell viability result. This work emphasises the promise of TYO-FeONPs gel as a dual-purpose therapeutic agent for dermal use as antibacterial and cytotoxic agent.

Graphical Abstract