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<p>To develop and optimize isovitexin-loaded liposomal gel formulations for enhanced topical acne treatment with improved skin permeation and therapeutic efficacy. Isovitexin-loaded liposomes were optimized using Box-Behnken design, incorporated into carbopol-based gels, and characterized for physicochemical properties, drug release, skin permeation, and stability. Statistical optimization identified F6 as optimal formulation with 91.25 ± 1.52% entrapment efficiency, 187.2 ± 5.8&#xa0;nm particle size, and 0.145 ± 0.006 polydispersity index. The optimized liposomal gel (LG1) demonstrated 2.84-fold enhanced skin permeation (42.67 ± 2.89&#xa0;µg/cm²/h) compared to plain gel (15.03 ± 1.23&#xa0;µg/cm²/h) with &gt; 97% drug retention over 90 days under accelerated conditions. The optimized isovitexin liposomal gel represents a promising advancement in topical acne therapy, offering superior skin penetration and sustained release characteristics suitable for clinical translation in dermatological applications.</p> Graphical Abstract <p></p>

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Development and Optimization of Isovitexin-Loaded Liposomal Gel for Acne Treatment

  • 期刊论文

  • 发表日期：

    2026年3月16日

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  • Shubham Nandkishor Girge,
  • Mahesh Hari Kolhe,
  • Gaurao Subhash Damre

摘要

To develop and optimize isovitexin-loaded liposomal gel formulations for enhanced topical acne treatment with improved skin permeation and therapeutic efficacy. Isovitexin-loaded liposomes were optimized using Box-Behnken design, incorporated into carbopol-based gels, and characterized for physicochemical properties, drug release, skin permeation, and stability. Statistical optimization identified F6 as optimal formulation with 91.25 ± 1.52% entrapment efficiency, 187.2 ± 5.8 nm particle size, and 0.145 ± 0.006 polydispersity index. The optimized liposomal gel (LG1) demonstrated 2.84-fold enhanced skin permeation (42.67 ± 2.89 µg/cm²/h) compared to plain gel (15.03 ± 1.23 µg/cm²/h) with > 97% drug retention over 90 days under accelerated conditions. The optimized isovitexin liposomal gel represents a promising advancement in topical acne therapy, offering superior skin penetration and sustained release characteristics suitable for clinical translation in dermatological applications.

Graphical Abstract