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<p><i>Thespesia populnea</i> has been traditionally used for treating a multitude of diseases. This work reports the green synthesis of AgNPs using the fruit extract of <i>Thespesia populnea</i>. The formulation of AgNPs was confirmed by the UV-Vis absorption peak at 420–430&#xa0;nm, whereas FTIR, XRD, SEM, and EDX revealed the presence of phytoconstituents, high crystallinity, particle size (~ 200&#xa0;nm), and elemental silver. Tp-AgNPs showed high colloidal stability, as evidenced from intense UV-Vis absorbance, more so at alkaline pH, and structure retention under variable conditions. Assays for antioxidant activities revealed potent activity: 81.2% DPPH and 69.45% hydroxyl radical scavenging. Nanoparticles exhibited pronounced antimicrobial activity against eight urinary tract pathogens. Maximum zones of inhibition were observed for <i>Staphylococcus aureus</i> and <i>Candida</i> spp., reaching up to 35&#xa0;mm at the highest tested volume of Tp-AgNPs; zones of inhibition for other bacteria ranged from 71% to 89%. Tp-AgNPs further exhibited potent anti-inflammatory potential as evidenced by the inhibition of protein denaturation (more than 90% inhibition at higher concentrations) and significant antidiabetic activity as evidenced by dose-dependent α-amylase and α-glucosidase enzyme inhibition. All these results emphasize that AgNPs fabricated using <i>T. populnea</i> are highly stable multifunctional nanomaterials and exhibit potent antioxidant, anti-inflammatory, antimicrobial, and antidiabetic activities, hence have therapeutic potential for the management of multidrug-resistant infections and oxidative stress-related disorders.</p>

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Therapeutic Applications of Thespesia populnea-Mediated Silver Nanoparticles: Synthesis, Characterization, and Multifunctional Bioactivities

  • 期刊论文

  • 发表日期：

    2026年3月11日

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  • C. M. Archana,
  • E. Kaarunya,
  • A. Aashiya,
  • Mukesh Kumar Dharmalingam Jothinathan,
  • Chanthini Kanagaraj Muthu-Pandian

摘要

Thespesia populnea has been traditionally used for treating a multitude of diseases. This work reports the green synthesis of AgNPs using the fruit extract of Thespesia populnea. The formulation of AgNPs was confirmed by the UV-Vis absorption peak at 420–430 nm, whereas FTIR, XRD, SEM, and EDX revealed the presence of phytoconstituents, high crystallinity, particle size (~ 200 nm), and elemental silver. Tp-AgNPs showed high colloidal stability, as evidenced from intense UV-Vis absorbance, more so at alkaline pH, and structure retention under variable conditions. Assays for antioxidant activities revealed potent activity: 81.2% DPPH and 69.45% hydroxyl radical scavenging. Nanoparticles exhibited pronounced antimicrobial activity against eight urinary tract pathogens. Maximum zones of inhibition were observed for Staphylococcus aureus and Candida spp., reaching up to 35 mm at the highest tested volume of Tp-AgNPs; zones of inhibition for other bacteria ranged from 71% to 89%. Tp-AgNPs further exhibited potent anti-inflammatory potential as evidenced by the inhibition of protein denaturation (more than 90% inhibition at higher concentrations) and significant antidiabetic activity as evidenced by dose-dependent α-amylase and α-glucosidase enzyme inhibition. All these results emphasize that AgNPs fabricated using T. populnea are highly stable multifunctional nanomaterials and exhibit potent antioxidant, anti-inflammatory, antimicrobial, and antidiabetic activities, hence have therapeutic potential for the management of multidrug-resistant infections and oxidative stress-related disorders.