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<p>Cutaneous leishmaniasis, a neglected tropical disease, required safer and more effective therapeutic strategies due to limitations of existing treatments. This study aimed to develop and optimize a curcumin-loaded polymeric nanogel for targeted therapy. Bovine serum albumin-based nanoparticles were synthesized using solvent evaporation and embedded into a gel matrix. A Box-Behnken Design was employed to optimize formulation parameters including polymer concentration, surfactant concentration, and homogenization speed. The optimized nanoparticles exhibited a particle size of 97.60&#xa0;nm, entrapment efficiency of 88.57%, and a sustained drug release of 83.98% over 24&#xa0;h. Scanning electron microscopy confirmed spherical morphology, while FTIR and DSC analyses confirmed drug-excipient compatibility. The developed nanogel displayed appropriate viscosity, pH (5.9), and high drug content (88.24%). Ex vivo diffusion studies demonstrated 15.56% release, and in vivo skin irritation studies confirmed biocompatibility with minimal adverse effects. Stability studies over 30&#xa0;days indicated consistent performance. This curcumin nanogel formulation held promise as a topical treatment for cutaneous leishmaniasis, offering improved drug delivery, reduced systemic toxicity, and enhanced patient compliance.</p>

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Curcumin-Loaded Polymeric Nanogel: Design, Optimization, and Characterization

  • 期刊论文

  • 发表日期：

    2026年2月4日

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  • Priya Patel,
  • Gokul H. Bhimajiyani,
  • Bhupendra G. Prajapati,
  • Devesh U. Kapoor

摘要

Cutaneous leishmaniasis, a neglected tropical disease, required safer and more effective therapeutic strategies due to limitations of existing treatments. This study aimed to develop and optimize a curcumin-loaded polymeric nanogel for targeted therapy. Bovine serum albumin-based nanoparticles were synthesized using solvent evaporation and embedded into a gel matrix. A Box-Behnken Design was employed to optimize formulation parameters including polymer concentration, surfactant concentration, and homogenization speed. The optimized nanoparticles exhibited a particle size of 97.60 nm, entrapment efficiency of 88.57%, and a sustained drug release of 83.98% over 24 h. Scanning electron microscopy confirmed spherical morphology, while FTIR and DSC analyses confirmed drug-excipient compatibility. The developed nanogel displayed appropriate viscosity, pH (5.9), and high drug content (88.24%). Ex vivo diffusion studies demonstrated 15.56% release, and in vivo skin irritation studies confirmed biocompatibility with minimal adverse effects. Stability studies over 30 days indicated consistent performance. This curcumin nanogel formulation held promise as a topical treatment for cutaneous leishmaniasis, offering improved drug delivery, reduced systemic toxicity, and enhanced patient compliance.