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<p>Nanotechnologies, due to their unique and diverse properties, have found numerous applications in biomedical fields. In this novel study, polyethylene glycol-coated copper oxide nanocomposites were synthesized using glycyrrhizic acid (PEG/CuO@GA-NCs) for enhanced biomedical applications. The PEG/CuO@GA-NCs were characterized using various spectroscopic techniques. UV–Vis spectroscopy confirmed that the PEG/CuO@GA-NCs had a maximum absorption at 270 and 330&#xa0;nm. The FTIR spectrum revealed several significant functional groups, while the XRD spectrum confirmed the peaks corresponding to the crystal structure. According to FESEM and HR-TEM studies, the particles were spherical and had an average size of 38.45&#xa0;nm. The PEG/CuO@GA-NCs exhibited potent antioxidant activity, with DPPH scavenging of 81.65 ± 1.65%. They also showed significant antibacterial activity against <i>Staphylococcus aureus</i>, with a zone of inhibition of 22.57 ± 0.96&#xa0;mm. The PEG/CuO@GA-NCs exhibited excellent enzyme inhibitory activities, showing anti-inflammatory effects against COX-2 (74.62 ± 1.15%) and antidiabetic activity against α-amylase (73.84 ± 1.83%). The nanocomposites demonstrated biocompatibility in zebrafish embryos up to a concentration of 100&#xa0;μg/mL. In the cytotoxicity study, at a concentration of 100&#xa0;µg/mL, a notable decrease in the survival rate of HeLa cervical cancer cells was observed, resulting in a 38.67 ± 0.52% decrease in cell viability. In conclusion, this study introduces GA as a novel co-factor in the synthesis of PEG/CuO@GA-NCs, enhancing their antioxidant, antibacterial, enzyme-inhibitory, and anticancer activities.</p>

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Development of Polyethylene Glycol–Coated CuO Nanocomposites for Enhanced Antioxidant, Antibacterial, Biocompatible and Anticancer Activities

  • 期刊论文

  • 发表日期：

    2025年12月14日

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  • Manickam Rajkumar,
  • S. I. Davis Presley,
  • Koyeli Girigoswami,
  • Asokan Sasireka,
  • Chinnaperumal Kamaraj,
  • Saranya Udayakumar,
  • Paramasivam Deepak

摘要

Nanotechnologies, due to their unique and diverse properties, have found numerous applications in biomedical fields. In this novel study, polyethylene glycol-coated copper oxide nanocomposites were synthesized using glycyrrhizic acid (PEG/CuO@GA-NCs) for enhanced biomedical applications. The PEG/CuO@GA-NCs were characterized using various spectroscopic techniques. UV–Vis spectroscopy confirmed that the PEG/CuO@GA-NCs had a maximum absorption at 270 and 330 nm. The FTIR spectrum revealed several significant functional groups, while the XRD spectrum confirmed the peaks corresponding to the crystal structure. According to FESEM and HR-TEM studies, the particles were spherical and had an average size of 38.45 nm. The PEG/CuO@GA-NCs exhibited potent antioxidant activity, with DPPH scavenging of 81.65 ± 1.65%. They also showed significant antibacterial activity against Staphylococcus aureus, with a zone of inhibition of 22.57 ± 0.96 mm. The PEG/CuO@GA-NCs exhibited excellent enzyme inhibitory activities, showing anti-inflammatory effects against COX-2 (74.62 ± 1.15%) and antidiabetic activity against α-amylase (73.84 ± 1.83%). The nanocomposites demonstrated biocompatibility in zebrafish embryos up to a concentration of 100 μg/mL. In the cytotoxicity study, at a concentration of 100 µg/mL, a notable decrease in the survival rate of HeLa cervical cancer cells was observed, resulting in a 38.67 ± 0.52% decrease in cell viability. In conclusion, this study introduces GA as a novel co-factor in the synthesis of PEG/CuO@GA-NCs, enhancing their antioxidant, antibacterial, enzyme-inhibitory, and anticancer activities.