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<p>Titanium dioxide (TiO<sub>2</sub>) nanoparticles are gaining prominence for their exceptional physicochemical and biological properties making them highly valuable in biomedical and environmental applications. Their high surface area, stability, biocompatibility and photocatalytic activity support uses in drug delivery, wound healing, antimicrobial treatments and tissue engineering. When combined with biopolymers like chitosan or gelatin, TiO<sub>2</sub> enhances mechanical strength and cell compatibility, aiding skin and bone regeneration. Stimuli-responsive TiO<sub>2</sub> systems enable targeted drug release triggered by pH, light or temperature. Metal doping and graphene integration further improve their performance in cancer therapy and biosensing. Green synthesis methods and advanced fabrication techniques like 3D printing are driving sustainable smart device development. Overall, TiO<sub>2</sub> nanocomposites represent a promising future in healthcare and environmental innovation.</p>

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Biomedical Potential of Tailored TiO2 Nanocomposites: Mechanistic Insights and Advanced Applications

  • 期刊论文

  • 发表日期：

    2025年12月14日

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  • Manivannan Govindasamy,
  • Harinathan Balasundaram,
  • Alexpandi Rajaiah,
  • Balasankar Thangasamy,
  • Vasantharaj Seerangaraj,
  • Mathiyazhagan Manickam,
  • Naveen Subbaiyan,
  • Ramesh Thangamani,
  • Packia Lekshmi N C J,
  • Nandagopal Siddan

摘要

Titanium dioxide (TiO2) nanoparticles are gaining prominence for their exceptional physicochemical and biological properties making them highly valuable in biomedical and environmental applications. Their high surface area, stability, biocompatibility and photocatalytic activity support uses in drug delivery, wound healing, antimicrobial treatments and tissue engineering. When combined with biopolymers like chitosan or gelatin, TiO2 enhances mechanical strength and cell compatibility, aiding skin and bone regeneration. Stimuli-responsive TiO2 systems enable targeted drug release triggered by pH, light or temperature. Metal doping and graphene integration further improve their performance in cancer therapy and biosensing. Green synthesis methods and advanced fabrication techniques like 3D printing are driving sustainable smart device development. Overall, TiO2 nanocomposites represent a promising future in healthcare and environmental innovation.