<p>Over the last few decades, there has been a substantial amount of research into polymers for a variety of biomedical applications, motivated by the exciting possibility of these materials for delivering next-generation therapies to patients. Polymeric degradable biomaterials have the considerable advantage of being able to be broken down and removed once they have fulfilled their purpose. Degradable polymers have numerous applications, including clinical use as sutures for surgery and implants. To meet functional demands, materials with the necessary physical, chemical, biological, biomechanical, and degrading qualities must be chosen. This review focus on evaluating the mechanical properties like Tensile Strength, Yield Strength, Youngs modulus, Impact strength, Friction, Coefficient Elongation, Density, Bending Strength of different polymers and the application of natural and synthetic polymers in orthopedic implants, dental implants, tissue and regenerative engineering, artificial kidney, cardiovascular applications, surgical sutures, wound healing, and drug delivery. This paper presents a comparative performance of different polymers used in similar kind of disease-based treatment processes showing positive and negative aspects.</p>