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<p>The intricate aspects of tumor biology, the diverse tumor microenvironment, and the challenges posed by conventional chemotherapy contribute to the complexities of managing skin cancer. Phytonanomedicine (PNM) is an innovative cancer treatment strategy that integrates bioactive compounds derived from plants with nanoscale delivery systems. This paper provides a detailed examination of the complex physical and chemical interactions of nanocarriers and their essential contribution to enhancing the distribution of plant-based medicines, skin penetration, and focused accumulation. The study showcases the potential of tailored nanoformulation to navigate biological obstacles, modify tumor microenvironments, and boost immunomodulatory and apoptotic mechanisms through the manipulation of nanoparticle size, surface properties, responsiveness to stimuli, and ligand-directed movement. Topics covered in this study include herbal nanocarrier-based drug delivery systems for skin cancer, tumor biology and microenvironment, cutaneous drug barriers, various phytochemicals, legislation, clinical translation, and future approaches in CRISPR and AI, among others. Recent developments in bioinspired, biomimetic, and hybrid nanotechnology systems that integrate plant-based actives with flexible delivery techniques are being explored for targeted cancer treatment applications. The most recent advances in PNM for the treatment of advanced skin cancer are discussed in this article. This review paper presents a fresh perspective on targeted therapy, an approach to skin cancer treatment that utilizes nanoparticles, and a methodology for both research and implementation. There has not been a review that covers such a broad variety of subjects&#xa0;as&#xa0;this&#xa0;one.</p>

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Physicochemical Engineering of Phyto-Nanotherapeutics for Precision-Targeted Therapy in Skin Cancer

  • 期刊论文

  • 发表日期：

    2025年8月5日

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  • Chethan Patil,
  • S. Oshik,
  • S. Yashwanth,
  • B. R. Darshan,
  • M. Yashwanth,
  • G. N. Vishwas,
  • B. J. Yashwanth,
  • D. Mohan Kumar,
  • Prasiddhi Naik,
  • Prakash Goudanavar

摘要

The intricate aspects of tumor biology, the diverse tumor microenvironment, and the challenges posed by conventional chemotherapy contribute to the complexities of managing skin cancer. Phytonanomedicine (PNM) is an innovative cancer treatment strategy that integrates bioactive compounds derived from plants with nanoscale delivery systems. This paper provides a detailed examination of the complex physical and chemical interactions of nanocarriers and their essential contribution to enhancing the distribution of plant-based medicines, skin penetration, and focused accumulation. The study showcases the potential of tailored nanoformulation to navigate biological obstacles, modify tumor microenvironments, and boost immunomodulatory and apoptotic mechanisms through the manipulation of nanoparticle size, surface properties, responsiveness to stimuli, and ligand-directed movement. Topics covered in this study include herbal nanocarrier-based drug delivery systems for skin cancer, tumor biology and microenvironment, cutaneous drug barriers, various phytochemicals, legislation, clinical translation, and future approaches in CRISPR and AI, among others. Recent developments in bioinspired, biomimetic, and hybrid nanotechnology systems that integrate plant-based actives with flexible delivery techniques are being explored for targeted cancer treatment applications. The most recent advances in PNM for the treatment of advanced skin cancer are discussed in this article. This review paper presents a fresh perspective on targeted therapy, an approach to skin cancer treatment that utilizes nanoparticles, and a methodology for both research and implementation. There has not been a review that covers such a broad variety of subjects as this one.