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<p>Gangrene is a severe and potentially life-threatening condition resulting from tissue necrosis due to inadequate blood supply or severe infection. Conventional treatments—such as antibiotics, surgical debridement, and amputation—often fail to fully address the complex pathophysiology of the disease. Hydrogels have emerged as promising alternatives, offering multifunctional therapeutic benefits. This review highlights hydrogel-based strategies for gangrene management, emphasizing their role in localized drug delivery, angiogenesis promotion, infection control, and tissue regeneration. Commonly used polymers in hydrogel formulations include polyethylene glycol (PEG), chitosan, and alginate, which offer desirable properties, such as biocompatibility, biodegradability, and tunable mechanical strength. Additionally, recent advances in stimuli-responsive or “smart” hydrogels—capable of reacting to changes in pH, temperature, or enzymatic activity—have expanded their potential in precision medicine. These systems can encapsulate drugs, growth factors, or stem cells to create a microenvironment conducive to wound healing. Ultimately, the intrinsic properties of hydrogels, including their biodegradability, mechanical resilience, and ability to support cellular activities, make them highly relevant for the effective treatment of gangrene. With continued research and innovation, hydrogel technologies hold significant promise to reduce the need for invasive interventions and improve patient outcomes.</p>

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Hydrogel-Based Strategies for Combating Gangrene: A Comprehensive Review of Therapeutic Mechanisms

  • 期刊论文

  • 发表日期：

    2025年8月5日

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  • M. Allen christopher,
  • Rithikha Sooriyaprakash,
  • Mohammed Avez Munawar,
  • Gokul Raj Gopinath,
  • Binoy Varghese Cheriyan,
  • Pavithra Bharathy

摘要

Gangrene is a severe and potentially life-threatening condition resulting from tissue necrosis due to inadequate blood supply or severe infection. Conventional treatments—such as antibiotics, surgical debridement, and amputation—often fail to fully address the complex pathophysiology of the disease. Hydrogels have emerged as promising alternatives, offering multifunctional therapeutic benefits. This review highlights hydrogel-based strategies for gangrene management, emphasizing their role in localized drug delivery, angiogenesis promotion, infection control, and tissue regeneration. Commonly used polymers in hydrogel formulations include polyethylene glycol (PEG), chitosan, and alginate, which offer desirable properties, such as biocompatibility, biodegradability, and tunable mechanical strength. Additionally, recent advances in stimuli-responsive or “smart” hydrogels—capable of reacting to changes in pH, temperature, or enzymatic activity—have expanded their potential in precision medicine. These systems can encapsulate drugs, growth factors, or stem cells to create a microenvironment conducive to wound healing. Ultimately, the intrinsic properties of hydrogels, including their biodegradability, mechanical resilience, and ability to support cellular activities, make them highly relevant for the effective treatment of gangrene. With continued research and innovation, hydrogel technologies hold significant promise to reduce the need for invasive interventions and improve patient outcomes.