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<p><i>Aspergillosis,</i> a life-threatening fungal infection, presents significant treatment challenges due to limited therapeutic options and drug toxicity. Posaconazole, though effective, suffers from poor solubility &amp; low bioavailability. This study aimed to develop a microemulsion-loaded chitosan transdermal film of Posaconazole to improve drug delivery and antifungal efficacy. The optimized microemulsion (MEP3) indicated size of the globules (20.52 nm), zeta potential (-2.77 mV) as well as encapsulated efficiency of the drug (94.81%). The developed transdermal film showed a sustained drug release and exhibited a cumulative release of 77.91% in 48-h and possessed good antifungal activity on a 29 mm zone of inhibition against <i>Aspergillus niger</i>. The present results indicate that the fabricated Posaconazole-chitosan film holds the potential to offer an upgrade on the control of <i>aspergillosis</i> by increasing the bio availability, slow release of the drug, and decrease the dosing frequency.</p> Graphical Abstract <p></p>

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Microemulsion-Loaded Chitosan Transdermal Films of Posaconazole for Targeted Aspergillosis Therapy

  • 期刊论文

  • 发表日期：

    2025年8月8日

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  • Koustav Dutta,
  • Biswajit Basu,
  • Rajdip Goswami,
  • Sourav Ghosh,
  • Meghamouli Rana,
  • Sajal Kumar Jha,
  • Bhupendra Prajapati

摘要

Aspergillosis, a life-threatening fungal infection, presents significant treatment challenges due to limited therapeutic options and drug toxicity. Posaconazole, though effective, suffers from poor solubility & low bioavailability. This study aimed to develop a microemulsion-loaded chitosan transdermal film of Posaconazole to improve drug delivery and antifungal efficacy. The optimized microemulsion (MEP3) indicated size of the globules (20.52 nm), zeta potential (-2.77 mV) as well as encapsulated efficiency of the drug (94.81%). The developed transdermal film showed a sustained drug release and exhibited a cumulative release of 77.91% in 48-h and possessed good antifungal activity on a 29 mm zone of inhibition against Aspergillus niger. The present results indicate that the fabricated Posaconazole-chitosan film holds the potential to offer an upgrade on the control of aspergillosis by increasing the bio availability, slow release of the drug, and decrease the dosing frequency.

Graphical Abstract