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<p>Borophosphate glass samples doped with calcium fluoride (CaF<sub>2</sub>), having the composition (60-x) NaPO<sub>3</sub>-25B<sub>2</sub>O<sub>3</sub>-xCaF<sub>2</sub>-15MgO with x varying at 2.5, 5, 7.5, 10, and 12.5&#xa0;mol%, were prepared using the melt-quenching technique. X-ray diffraction (XRD) analysis validated their amorphous characteristics, indicating the absence of long-range crystalline order. Fourier transform infrared (FTIR) spectroscopy revealed compositional modifications within the borate and phosphate glass networks, suggesting changes in structural connectivity and bonding. To assess bioactivity, the glasses were immersed in simulated body fluid (SBF) for 3, 7, 14, and 21&#xa0;days. Post-immersion characterization using XRD and FTIR confirmed the formation of hydroxyapatite (HAp) and fluorapatite (FAp) layers on the surface of the glass samples, demonstrating their bioactive nature. A reduction in pH after immersion indicated ion exchange processes contributing to apatite layer formation. Scanning electron microscopy (SEM) revealed crystal agglomerates on the glass surfaces, while energy dispersive X-ray (EDX) analysis detected the presence of calcium (Ca) and phosphorus (P) ions, further supporting apatite phase formation. These results indicate that the prepared glass samples display notable bioactive characteristics, making them promising candidates for use in biomedical fields, particularly in bone tissue engineering and dental restoration. The investigation provides significant understanding of the structural and chemical interactions of these glasses in physiological conditions, highlighting their potential as bioactive materials.</p>

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Evaluation of the Bioactive Properties of Calcium Fluoride Doped Borophosphate Glasses

  • 期刊论文

  • 发表日期：

    2025年7月10日

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  • Harish Madival,
  • Asha Rajiv

摘要

Borophosphate glass samples doped with calcium fluoride (CaF2), having the composition (60-x) NaPO3-25B2O3-xCaF2-15MgO with x varying at 2.5, 5, 7.5, 10, and 12.5 mol%, were prepared using the melt-quenching technique. X-ray diffraction (XRD) analysis validated their amorphous characteristics, indicating the absence of long-range crystalline order. Fourier transform infrared (FTIR) spectroscopy revealed compositional modifications within the borate and phosphate glass networks, suggesting changes in structural connectivity and bonding. To assess bioactivity, the glasses were immersed in simulated body fluid (SBF) for 3, 7, 14, and 21 days. Post-immersion characterization using XRD and FTIR confirmed the formation of hydroxyapatite (HAp) and fluorapatite (FAp) layers on the surface of the glass samples, demonstrating their bioactive nature. A reduction in pH after immersion indicated ion exchange processes contributing to apatite layer formation. Scanning electron microscopy (SEM) revealed crystal agglomerates on the glass surfaces, while energy dispersive X-ray (EDX) analysis detected the presence of calcium (Ca) and phosphorus (P) ions, further supporting apatite phase formation. These results indicate that the prepared glass samples display notable bioactive characteristics, making them promising candidates for use in biomedical fields, particularly in bone tissue engineering and dental restoration. The investigation provides significant understanding of the structural and chemical interactions of these glasses in physiological conditions, highlighting their potential as bioactive materials.