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<p>It is essential to fix damaged tissue in diabetic wounds to minimize the chances of the amputation of limbs in millions of diabetic people around the world.Solid lipid nanoparticles (SLNs) have gained more attention from researchers due to their high biocompatibility level and can make it easier to dissolve low-solubility drugs. The current study uses the hot-melt sonication method to formulate SLNs that are loaded with a model drug neomycin sulfate (NES), with a low-solubility profile. Optimization of process parameters in developing NES-SLN has been attempted with a Box-Behnken design. Based on the desirability approach, 384.36&#xa0;mg of lipid, 176.96&#xa0;mg of surfactant, and 249.54&#xa0;mg of chitosan can meet the prerequisites of an ideal SLN formulation, which has a particle size (PS) of 142.34&#xa0;nm and an entrapment efficiency of 82.29%. The optimized formula was further loaded to fabricate films (NES-SLN-F) and characterized for various parameters. The in vitro drug release profile showed that 92.54% of the NES was released for up to 72&#xa0;h. NES-SLN-F was further shown to have desired anti-microbial activity. The in vitro scratch test shows that the formula accelerates wound healing. The in vivo studies demonstrated the effectiveness of NES-SLN-F in reducing both short-term and long-term inflammations. Hence, NES-SLN-F might be regarded as an appropriate candidate for wound dressing.</p> Graphical Abstract <p></p>

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Exploration of Solid Lipid Nanoparticles-Loaded Films as a Wound Healing Drug Delivery System: In Vitro and In Vivo Studies

  • 期刊论文

  • 发表日期：

    2025年6月17日

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  • Vinay kumar chakravarthy Maddikunta,
  • Rajkumari Thagele,
  • Kumaraswamy Gandla

摘要

It is essential to fix damaged tissue in diabetic wounds to minimize the chances of the amputation of limbs in millions of diabetic people around the world.Solid lipid nanoparticles (SLNs) have gained more attention from researchers due to their high biocompatibility level and can make it easier to dissolve low-solubility drugs. The current study uses the hot-melt sonication method to formulate SLNs that are loaded with a model drug neomycin sulfate (NES), with a low-solubility profile. Optimization of process parameters in developing NES-SLN has been attempted with a Box-Behnken design. Based on the desirability approach, 384.36 mg of lipid, 176.96 mg of surfactant, and 249.54 mg of chitosan can meet the prerequisites of an ideal SLN formulation, which has a particle size (PS) of 142.34 nm and an entrapment efficiency of 82.29%. The optimized formula was further loaded to fabricate films (NES-SLN-F) and characterized for various parameters. The in vitro drug release profile showed that 92.54% of the NES was released for up to 72 h. NES-SLN-F was further shown to have desired anti-microbial activity. The in vitro scratch test shows that the formula accelerates wound healing. The in vivo studies demonstrated the effectiveness of NES-SLN-F in reducing both short-term and long-term inflammations. Hence, NES-SLN-F might be regarded as an appropriate candidate for wound dressing.

Graphical Abstract