Nanozymes as Next-Generation Therapeutics: Synergizing Enzyme-Mimetic Activity with Nanoscale Features
摘要
Nanozymes are synthetic nanomaterials that emulate the catalytic functions of natural enzymes, offering promising solutions to the inherent limitations of their biological counterparts. These materials have garnered global research interest due to their superior stability, cost-effectiveness, tuneable activity, and multifunctionality. Beyond mimicking enzymatic activity, nanozymes leverage unique nanoscale properties such as magnetism, optical responsiveness, and infrared absorbance, enabling enhanced performance in diverse biomedical contexts. Compared to natural enzymes, they demonstrate greater durability, broader functionality, and lower production costs. Therapeutically, nanozymes have shown potential in a wide range of applications, including anti-inflammatory, antiviral, antioxidant, antithrombotic, and regenerative medicine. To maximize their utility, integrating enzymatic functions with nanoscale characteristics such as optical, magnetic, and mechanical properties are essential. This concise review highlights recent advances in the biomedical applications of nanozymes, particularly in antiviral, antibacterial, anti-inflammatory, and tissue-regenerative therapies, emphasizing their emerging role in next-generation nanotherapeutics.
Graphical Abstract