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<p>In this study, the composite nanofibers composed of polyvinyl alcohol (PVA) reinforced with titanium dioxide (TiO<sub>2</sub>) nanoparticles (TiO<sub>2</sub>@PVA) were successfully fabricated by electrospinning technique. X-ray diffraction (XRD) analysis validated the integration of TiO<sub>2</sub> within the PVA nanofibrous framework, revealed distinct anatase crystal structures. Fourier-transform infrared (FTIR) spectra exhibited spectral shifts, suggesting intermolecular interactions between TiO<sub>2</sub> and PVA chains. The presence of TiO<sub>2</sub> broadened the UV absorption capacity of the TiO<sub>2</sub>@PVA nanofibrous matrix, contributing to improved antibacterial performance. Observed tunable wettability upon TiO<sub>2</sub> integration showed an elevated water contact angle (~ 59.32°) due to the improved surface hydrophobicity. Antioxidant potential (DPPH radical scavenging activity) was enhanced due to the inherent redox activity of TiO<sub>2</sub> nanoparticles. Antibacterial study demonstrated significant activity against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, with MIC values between 2.5 and 5&#xa0;mg/ml and MBC around 5&#xa0;mg/mL. Biocompatibility was confirmed through zebrafish embryo survivability over 72&#xa0;h post-fertilization. Overall, these findings suggest that TiO<sub>2</sub>@PVA electrospun composite nanofibers would be promising candidates for wound dressing applications owing to their tunable wettability and antibacterial property.</p>

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Tunable Wettability and Antibacterial Potential of TiO2@PVA Electrospun Composite Nanofibers

  • 期刊论文

  • 发表日期：

    2025年6月5日

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  • P. Manu Preetha,
  • J. Ramana Ramya,
  • Nitya Krishnasamy,
  • Radha Gosala

摘要

In this study, the composite nanofibers composed of polyvinyl alcohol (PVA) reinforced with titanium dioxide (TiO2) nanoparticles (TiO2@PVA) were successfully fabricated by electrospinning technique. X-ray diffraction (XRD) analysis validated the integration of TiO2 within the PVA nanofibrous framework, revealed distinct anatase crystal structures. Fourier-transform infrared (FTIR) spectra exhibited spectral shifts, suggesting intermolecular interactions between TiO2 and PVA chains. The presence of TiO2 broadened the UV absorption capacity of the TiO2@PVA nanofibrous matrix, contributing to improved antibacterial performance. Observed tunable wettability upon TiO2 integration showed an elevated water contact angle (~ 59.32°) due to the improved surface hydrophobicity. Antioxidant potential (DPPH radical scavenging activity) was enhanced due to the inherent redox activity of TiO2 nanoparticles. Antibacterial study demonstrated significant activity against Escherichia coli and Staphylococcus aureus, with MIC values between 2.5 and 5 mg/ml and MBC around 5 mg/mL. Biocompatibility was confirmed through zebrafish embryo survivability over 72 h post-fertilization. Overall, these findings suggest that TiO2@PVA electrospun composite nanofibers would be promising candidates for wound dressing applications owing to their tunable wettability and antibacterial property.