Scholarlink

<p>Transdermal drug delivery systems (TDDS) have emerged as a promising substitute to oral routes of drug administration. TDDS offers several advantages, including avoiding presystemic metabolism, improving patient compliance, reducing side effects, and providing controlled drug release. This review comprehensively explores the components, preparation methods, and recent developments in transdermal patches. Drug, polymer matrix, adhesive, backing layer, and release liner are the fundamental parts of a transdermal patch. Natural polymers like xanthan gum, sodium alginate, and chitosan, as well as synthetic polymers such as polyvinylpyrrolidone and ethyl cellulose, are commonly used in TDDS. Transdermal patches can be prepared by employing various techniques, such as solvent casting method, aluminum-backed adhesive film method, circular Teflon mold method, free film method, along with mercury substrate method. Evaluation techniques for transdermal patches, such as thickness, folding endurance, drug content, weight uniformity, along with in vitro drug release investigations, are also described. Recent advancements in transdermal patch methodology include smart patch development with sensors for monitoring and adjusting drug delivery, 3D-printed patches for personalized medicine, high drug loading along with controlled-release patches, and biodegradable patches. The potential applications of transdermal patches in vaccination, gene therapy, cardiovascular diseases, and insulin delivery are highlighted. Transdermal drug delivery devices have the potential to transform drug administration and enhance patient outcomes in several therapeutic areas with continued research and advancements.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Transdermal Patches: Design, Evaluation, and Potential Applications in Modern Therapeutics

  • 期刊论文

  • 发表日期：

    2025年5月16日

查看全文
  • Pooja Kulkarni,
  • Khaja Anees Ahmed,
  • Sidramappa B. Shirsand,
  • Prerana K. Raikar,
  • Aniket Hiraskar

摘要

Transdermal drug delivery systems (TDDS) have emerged as a promising substitute to oral routes of drug administration. TDDS offers several advantages, including avoiding presystemic metabolism, improving patient compliance, reducing side effects, and providing controlled drug release. This review comprehensively explores the components, preparation methods, and recent developments in transdermal patches. Drug, polymer matrix, adhesive, backing layer, and release liner are the fundamental parts of a transdermal patch. Natural polymers like xanthan gum, sodium alginate, and chitosan, as well as synthetic polymers such as polyvinylpyrrolidone and ethyl cellulose, are commonly used in TDDS. Transdermal patches can be prepared by employing various techniques, such as solvent casting method, aluminum-backed adhesive film method, circular Teflon mold method, free film method, along with mercury substrate method. Evaluation techniques for transdermal patches, such as thickness, folding endurance, drug content, weight uniformity, along with in vitro drug release investigations, are also described. Recent advancements in transdermal patch methodology include smart patch development with sensors for monitoring and adjusting drug delivery, 3D-printed patches for personalized medicine, high drug loading along with controlled-release patches, and biodegradable patches. The potential applications of transdermal patches in vaccination, gene therapy, cardiovascular diseases, and insulin delivery are highlighted. Transdermal drug delivery devices have the potential to transform drug administration and enhance patient outcomes in several therapeutic areas with continued research and advancements.