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<p>Zinc oxide nanoparticles (ZnO NPs) were synthesized using <i>Pentatropis capensis</i> leaf extracts and characterized through multiple analytical techniques, including SEM&#xa0;with EDAX, XRD, FTIR, and UV–Visible spectroscopy. The UV–Visible test confirmed an absorption peak at 373&#xa0;nm and the SEM with EDAX results showed that the ZnO NPs were spherical shape. Antibacterial studies demonstrated significant inhibition of <i>Staphylococcus aureus</i>, with a 25&#xa0;mm zone of inhibition at 75&#xa0;μg/mL.&#xa0;The ZnO NPs exhibited notable antioxidant activity, with an IC<sub>50</sub> value of 105.61 μg/mL for ABTS and&#xa0;101.89&#xa0;μg/mL for DPPH assays. In terms of anti-inflammatory potential, the IC<sub>50</sub> values were determined to be 79.86&#xa0;μg/mL for HRBC membrane stabilization and 83.74&#xa0;μg/mL for albumin denaturation inhibition. Additionally, cytotoxicity analysis against HT-29 colon cancer cell line using the MTT assay yielded an IC<sub>50</sub> value of 95.37&#xa0;μg/mL. These findings highlight the therapeutic potential of <i>Pentatropis capensis</i>-derived ZnO NPs, emphasizing their promising role in nanomedicine applications.</p> Graphical Abstract <p></p>

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Green Synthesis of Zinc Oxide Nanoparticles Using Pentatropis capensis (L.f) Bullock Leaf Extract: Characterization, Antibacterial, Antioxidant, Anti-Inflammatory and Cytotoxicity Studies

  • 期刊论文

  • 发表日期：

    2025年5月6日

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  • Lavanya Ganesan,
  • Maruthupandian Arumugam,
  • Viji Maluventhen

摘要

Zinc oxide nanoparticles (ZnO NPs) were synthesized using Pentatropis capensis leaf extracts and characterized through multiple analytical techniques, including SEM with EDAX, XRD, FTIR, and UV–Visible spectroscopy. The UV–Visible test confirmed an absorption peak at 373 nm and the SEM with EDAX results showed that the ZnO NPs were spherical shape. Antibacterial studies demonstrated significant inhibition of Staphylococcus aureus, with a 25 mm zone of inhibition at 75 μg/mL. The ZnO NPs exhibited notable antioxidant activity, with an IC50 value of 105.61 μg/mL for ABTS and 101.89 μg/mL for DPPH assays. In terms of anti-inflammatory potential, the IC50 values were determined to be 79.86 μg/mL for HRBC membrane stabilization and 83.74 μg/mL for albumin denaturation inhibition. Additionally, cytotoxicity analysis against HT-29 colon cancer cell line using the MTT assay yielded an IC50 value of 95.37 μg/mL. These findings highlight the therapeutic potential of Pentatropis capensis-derived ZnO NPs, emphasizing their promising role in nanomedicine applications.

Graphical Abstract