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<p>Nanotechnology is an emerging field that focuses on manipulating materials at the nanoscale, with a growing emphasis on green synthesis methods to create eco&#xa0;friendly and biocompatible nanoparticles. The use of plant&#xa0;derived bioactive compounds for the synthesis of copper nanoparticles (CuNPs) presents a sustainable, green approach. In this study, bioactive compounds from <i>Acacia auriculiformis</i> were utilized to synthesize CuNPs. The formation of CuNPs was confirmed by UV–visible spectroscopy, with a characteristic peak observed at 380&#xa0;nm. FTIR analysis confirmed the presence of functional groups like hydroxyl, aromatic, alkane, ether and Cu–O vibrations, indicating their role in CuNPs reduction, stabilization and oxide layer formation. SEM–EDX analysis revealed that the nanoparticles were spherical in shape and primarily composed of copper and oxygen. The antioxidant activity of the synthesized CuNPs was evaluated through various assays, including DPPH, ABTS, FRAP, nitric oxide and H₂O₂, demonstrating strong free radical scavenging capabilities. Additionally, embryotoxicity tests using zebrafish embryos were conducted to assess the biocompatibility of CuNPs at different concentrations, focusing on hatching rates, viability and morphological development. The results showed concentration&#xa0;dependent toxicity, with minimal effects on embryonic development at lower concentrations (5&#xa0;µg/mL). These findings suggest that CuNPs synthesized using <i>A. auriculiformis</i> bioactive compounds offer potent antioxidant properties and exhibit reduced toxicity at lower concentrations, although higher concentrations may cause oxidative stress and impair embryonic development. This study provides valuable insights into optimizing CuNPs concentration for safety, with potential for future modifications to enhance their therapeutic compatibility for biomedical and environmental applications.</p> Graphical Abstract <p></p>

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Synergistic Synthesis of Copper Nanoparticles via Bioactive Compounds from Acacia auriculiformis: Embryonic Toxicology and In Vitro Antioxidant Evaluation

  • 期刊论文

  • 发表日期：

    2025年4月1日

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  • Iadalin Ryntathiang,
  • Mathangi Vinayakar Senthilkumar,
  • Archana Behera,
  • Namrutha Dhonthi Shekar,
  • Saantosh Saravanan,
  • Mukesh Kumar Dharmalingam Jothinathan,
  • Dharmalingam Kirubakaran

摘要

Nanotechnology is an emerging field that focuses on manipulating materials at the nanoscale, with a growing emphasis on green synthesis methods to create eco friendly and biocompatible nanoparticles. The use of plant derived bioactive compounds for the synthesis of copper nanoparticles (CuNPs) presents a sustainable, green approach. In this study, bioactive compounds from Acacia auriculiformis were utilized to synthesize CuNPs. The formation of CuNPs was confirmed by UV–visible spectroscopy, with a characteristic peak observed at 380 nm. FTIR analysis confirmed the presence of functional groups like hydroxyl, aromatic, alkane, ether and Cu–O vibrations, indicating their role in CuNPs reduction, stabilization and oxide layer formation. SEM–EDX analysis revealed that the nanoparticles were spherical in shape and primarily composed of copper and oxygen. The antioxidant activity of the synthesized CuNPs was evaluated through various assays, including DPPH, ABTS, FRAP, nitric oxide and H₂O₂, demonstrating strong free radical scavenging capabilities. Additionally, embryotoxicity tests using zebrafish embryos were conducted to assess the biocompatibility of CuNPs at different concentrations, focusing on hatching rates, viability and morphological development. The results showed concentration dependent toxicity, with minimal effects on embryonic development at lower concentrations (5 µg/mL). These findings suggest that CuNPs synthesized using A. auriculiformis bioactive compounds offer potent antioxidant properties and exhibit reduced toxicity at lower concentrations, although higher concentrations may cause oxidative stress and impair embryonic development. This study provides valuable insights into optimizing CuNPs concentration for safety, with potential for future modifications to enhance their therapeutic compatibility for biomedical and environmental applications.

Graphical Abstract