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<p>Nanotechnology is a crucial field that is being widely researched in various fields. This innovative study investigates the synthesis of cerium oxide nanoparticles (CeO<sub>2</sub>NPs) using an extract from the plant <i>Alternanthera sessilis</i> and its various biological applications. Several methods, such as UV–Vis spectroscopy, FTIR, XRD, FESEM, HR-TEM, and DLS analysis, were used to confirm the nature of the synthesized CeO<sub>2</sub>NPs. In this study result, the UV–Vis spectroscopy maximum absorption peak at 326&#xa0;nm proved that CeO<sub>2</sub>NPs were present. FTIR analysis identified several functional groups, while XRD confirmed their crystal structure. It was seen in FESEM and HR-TEM images that CeO<sub>2</sub>NPs were mostly spherical and oval, and their average size was 29&#xa0;nm. CeO<sub>2</sub>NPs exhibited impressive antioxidant properties and exhibited significant antibacterial activity against <i>E. coli</i> (25.04 ± 1.45&#xa0;mm) and <i>S. aureus</i> (23.97 ± 1.29&#xa0;mm). CeO<sub>2</sub>NPs showed significant anti-inflammatory effects by inhibiting COX-1 (80.91 ± 1.22%) and COX-2 (71.58 ± 1.16%). CeO<sub>2</sub>NPs showed strong enzyme-inhibitory activity against α-amylase (70.46 ± 1.37%), α-glucosidase (79.58 ± 1.37%), acetylcholinesterase (68.92 ± 1.39%), and butylcholinesterase (73.47 ± 1.53%). Cytotoxicity assays showed that CeO<sub>2</sub>NPs significantly reduced cell viability by 28.59 ± 0.39% in HepG2 cancer cells. In conclusion, this study shows that the green-synthesized CeO<sub>2</sub>NPs is a non-toxic, cost-effective and safe method, making it a very promising alternative for various biological applications.</p>

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Biosynthesis of Cerium Oxide Nanoparticles Using Alternanthera sessilis Leaf Extract and Evaluation of their Antioxidant, Antibacterial, Anti-Inflammatory, Antidiabetic and Cytotoxic Activities

  • 期刊论文

  • 发表日期：

    2025年3月4日

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  • Manickam Rajkumar,
  • S. I. Davis Presley,
  • Prabha Govindaraj,
  • Krishnan Meenambigai,
  • Thandapani Gomathi,
  • Musab Mohammad Al-Essa,
  • Farid Menaa

摘要

Nanotechnology is a crucial field that is being widely researched in various fields. This innovative study investigates the synthesis of cerium oxide nanoparticles (CeO2NPs) using an extract from the plant Alternanthera sessilis and its various biological applications. Several methods, such as UV–Vis spectroscopy, FTIR, XRD, FESEM, HR-TEM, and DLS analysis, were used to confirm the nature of the synthesized CeO2NPs. In this study result, the UV–Vis spectroscopy maximum absorption peak at 326 nm proved that CeO2NPs were present. FTIR analysis identified several functional groups, while XRD confirmed their crystal structure. It was seen in FESEM and HR-TEM images that CeO2NPs were mostly spherical and oval, and their average size was 29 nm. CeO2NPs exhibited impressive antioxidant properties and exhibited significant antibacterial activity against E. coli (25.04 ± 1.45 mm) and S. aureus (23.97 ± 1.29 mm). CeO2NPs showed significant anti-inflammatory effects by inhibiting COX-1 (80.91 ± 1.22%) and COX-2 (71.58 ± 1.16%). CeO2NPs showed strong enzyme-inhibitory activity against α-amylase (70.46 ± 1.37%), α-glucosidase (79.58 ± 1.37%), acetylcholinesterase (68.92 ± 1.39%), and butylcholinesterase (73.47 ± 1.53%). Cytotoxicity assays showed that CeO2NPs significantly reduced cell viability by 28.59 ± 0.39% in HepG2 cancer cells. In conclusion, this study shows that the green-synthesized CeO2NPs is a non-toxic, cost-effective and safe method, making it a very promising alternative for various biological applications.